Peripheral spectrum neurological disorder after arbovirus infection is associated with HLA-F variants among Northeastern Brazilians
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Data
2021-08-01
Autores
Sonon, Paulin
Collares, Cristhianna V.A.
Ferreira, Maria Lúcia Brito
Almeida, Renata Santos
Sadissou, Ibrahim
Cordeiro, Marli Tenório
de Fátima Militão de Albuquerque, Maria
Castelli, Erick C. [UNESP]
Lucena-Silva, Norma
Donadi, Eduardo A.
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Introduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T CD8+) during viral infection by interacting with inhibitory/activating receptors. However, little is known about the HLA-E/-F genetic variability on arbovirus infections. Methods: We evaluated by massive parallel sequencing the full HLA-E/-F genetic diversity among patients infected during the arbovirus (ZIKV, DENV, and CHIKV) outbreak leading to a broad range of neurological complications in the Brazilian State of Pernambuco. In parallel, healthy blood donors from the same area were also studied. Plink and R software were used for genetic association study. To limit the false-positive results and enhance the reliability of the results, we adopted P-values <0.01 as significant levels. Results: Compared to controls, the HLA-F alleles: −1610 C (rs17875375), +1383 G (rs17178385), and +3537 A (rs17875384), all in complete linkage disequilibrium with each other (r2 = 1), were overrepresented in patients presenting peripheral spectrum disorders (PSD). The HLA-F*Distal-D haplotype that harbored the −1610 C allele exhibited a trend increase in PSD group. No associations were found for HLA-E. Conclusions: Our findings showed that the HLA-F genetic background seems to be more important than HLA-E on the susceptibility to PSD complications.
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Arbovirus, ESD, HLA-E, HLA-F, Pernambuco, PSD
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Infection, Genetics and Evolution, v. 92.