In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bone regeneration
Nenhuma Miniatura disponível
Data
2021-01-01
Autores
Oshiro-Junior, João Augusto [UNESP]
Barros, Rafaela Moreno
da Silva, Camila Garcia [UNESP]
de Souza, Caroline Cordeiro [UNESP]
Scardueli, Cássio Rocha [UNESP]
Marcantonio, Camila Chiérici [UNESP]
da Silva Saches, Paulo Ricardo [UNESP]
Mendes, Larissa [UNESP]
Cilli, Eduardo Maffud [UNESP]
Marcantonio, Rosemary Adriana Chierici [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, benefiting more than 2.2 million patients annually. The objective of this work was to develop membranes from ureasil-polyether materials containing OGP. The membranes were characterized by differential scanning calorimetry (DSC) and small angle X-ray scattering (SAXS). OGP was synthesized by the solid phase method. Sterilization results using gamma radiation at 24 kGy did not change the structure of the material, as confirmed by DSC. The SAXS technique revealed the structural homogeneity of the matrix. OGP was incorporated in 66.25 × 10−10 mol and release results showed that the ureasil-PPO400/PEO500 and ureasil-PPO400/PEO1900 membranes released 7% and 21%, respectively, after 48 h. In vivo results demonstrated that the amount and quality of bone tissue formed in the bone defects in the presence of ureasil-polyether membranes with OGP were similar to commercial collagen material with BMP. The results allow us to conclude that membranes with OGP have characteristics that make them potential candidates for the GBR.
Descrição
Palavras-chave
bone morphogenetic proteins, critical-sized bone defects, osteoinductive membrane, ureasil-polyether materials
Como citar
Journal of Tissue Engineering and Regenerative Medicine.