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dc.contributor.authorCalanca, Naiade [UNESP]
dc.contributor.authorAbildgaard, Cecilie
dc.contributor.authorRainho, Cláudia Aparecida [UNESP]
dc.contributor.authorRogatto, Silvia Regina
dc.date.accessioned2021-06-25T11:04:39Z
dc.date.available2021-06-25T11:04:39Z
dc.date.issued2020-09-01
dc.identifierhttp://dx.doi.org/10.3390/cancers12092701
dc.identifier.citationCancers, v. 12, n. 9, p. 1-21, 2020.
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/11449/207997
dc.description.abstractComprehensive large-scale sequencing and bioinformatics analyses have uncovered a myriad of cancer-associated long noncoding RNAs (lncRNAs). Aberrant expression of lncRNAs is associated with epigenetic reprogramming during tumor development and progression, mainly due to their ability to interact with DNA, RNA, or proteins to regulate gene expression. LncRNAs participate in the control of gene expression patterns during development and cell differentiation and can be cell and cancer type specific. In this review, we described the potential of lncRNAs for clinical applications in ovarian cancer (OC). OC is a complex and heterogeneous disease characterized by relapse, chemoresistance, and high mortality rates. Despite advances in diagnosis and treatment, no significant improvements in long-term survival were observed in OC patients. A set of lncRNAs was associated with survival and response to therapy in this malignancy. We manually curated databases and used bioinformatics tools to identify lncRNAs implicated in the epigenetic regulation, along with examples of direct interactions between the lncRNAs and proteins of the epigenetic machinery in OC. The resources and mechanisms presented herein can improve the understanding of OC biology and provide the basis for further investigations regarding the selection of novel biomarkers and therapeutic targets.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1-21
dc.language.isoeng
dc.relation.ispartofCancers
dc.sourceScopus
dc.subjectEpigenetic regulators
dc.subjectLncRNA databases
dc.subjectLncRNAs
dc.subjectOvarian cancer
dc.subjectTranscriptional regulation
dc.titleThe interplay between long noncoding rnas and proteins of the epigenetic machinery in ovarian canceren
dc.typeResenha
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Southern Denmark
dc.description.affiliationDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Oncology University Hospital of Southern Denmark-Vejle Institute of Regional Health Research University of Southern Denmark
dc.description.affiliationDepartment of Clinical Genetics University Hospital of Southern Denmark-Vejle Institute of Regional Health Research University of Southern Denmark
dc.description.affiliationUnespDepartment of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)
dc.identifier.doi10.3390/cancers12092701
dc.identifier.scopus2-s2.0-85091638720
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