Show simple item record

dc.contributor.authorFranz-Montan, Michelle
dc.contributor.authorBergamaschi, Cristiane de Cassia
dc.contributor.authorde Paula, Eneida
dc.contributor.authorGroppo, Francisco C.
dc.contributor.authorRanali, Jose
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorVolpato, Maria C.
dc.identifier.citationJournal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 10, p. 1945-1951, 2010.
dc.description.abstractThe aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC(0-24) (area under the plasma concentration x time curve from baseline to 24 h), AUC(0-infinity) (area under the plasma concentration-time curve from baseline to infinity), C-max (maximum drug concentration), CL (renal clearance), T-max (maximum drug concentration time), t(1/2) (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.sourceWeb of Science
dc.subjectlocal anesthesiaen
dc.titlePharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesiaen
dcterms.rightsHolderSoc Brasileira Quimica
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, Brazil
dc.description.affiliationJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.affiliationUnespJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, Brazil
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 06/00121-9
dc.description.sponsorshipIdFAPESP: 06/53255-2
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt[7][4]
Localize o texto completo

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record