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dc.contributor.authorFranz-Montan, Michelle
dc.contributor.authorBergamaschi, Cristiane de Cassia
dc.contributor.authorde Paula, Eneida
dc.contributor.authorGroppo, Francisco C.
dc.contributor.authorRanali, Jose
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorVolpato, Maria C.
dc.date.accessioned2014-05-20T13:12:13Z
dc.date.available2014-05-20T13:12:13Z
dc.date.issued2010-01-01
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532010001000021
dc.identifier.citationJournal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 10, p. 1945-1951, 2010.
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/11449/207
dc.description.abstractThe aim of this study was to determine the pharmacokinetic parameters of liposomal ropivacaine after dental anesthesia in 14 healthy volunteers. In this randomized, double-blind and crossover study, the volunteers received maxillary infiltration of liposome-encapsulated 0.5% ropivacaine and, 0.5% ropivacaine with 1:200,000 epinephrine in two different sessions. Blood samples were collected before and after (from 15 to 1440 min) the administration of either ropivacaine formulation. HPLC with UV detection was used to quantify plasma ropivacaine concentrations. The pharmacokinetic parameters AUC(0-24) (area under the plasma concentration x time curve from baseline to 24 h), AUC(0-infinity) (area under the plasma concentration-time curve from baseline to infinity), C-max (maximum drug concentration), CL (renal clearance), T-max (maximum drug concentration time), t(1/2) (elimination half-life) and Vd (volume of distribution) were analyzed using the Wilcoxon signed-rank test. No differences (p > 0.05) were observed between both formulations for any of the pharmacokinetic parameters evaluated and plasma ropivacaine concentrations, considering each period of time. Both formulations showed similar pharmacokinetic profiles, indicating that the liposomal formulation could be a safer option for use of this local anesthetic, due to the absence of a vasoconstrictor.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1945-1951
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.sourceWeb of Science
dc.subjectropivacaineen
dc.subjectlocal anesthesiaen
dc.subjectdentistryen
dc.subjectliposomeen
dc.subjectpharmacokineticen
dc.titlePharmacokinetic Profile of Liposome-Encapsulated Ropivacaine after Maxillary Infiltration Anaesthesiaen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, Brazil
dc.description.affiliationJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.affiliationUnespJulio de Mesquita Filho State Univ, Dept Environm Engn, Sorocaba, SP, Brazil
dc.identifier.doi10.1590/S0103-50532010001000021
dc.identifier.scieloS0103-50532010001000021
dc.identifier.wosWOS:000282709800020
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 06/00121-9
dc.description.sponsorshipIdFAPESP: 06/53255-2
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt
unesp.author.orcid0000-0002-1459-7050[7]
unesp.author.orcid0000-0002-8513-773X[4]
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
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