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dc.contributor.authorKokubun, Eduardo [UNESP]
dc.contributor.authorHirabara, Sandro A.
dc.contributor.authorFiamoncini, Jarlei
dc.contributor.authorCuri, Rui
dc.contributor.authorHaebisch, Horst
dc.identifier.citationCell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 27, n. 7, p. 488-495, 2009.
dc.description.abstractGlycogen content of white and red skeletal muscles, cardiac muscle, and liver was investigated in conditions where changes in plasma levels of non-esterified fatty acids (NEFA) occur. The experiments were performed in fed and 12 and 48 h-fasted rats. The animals were also submitted to swimming for 10 and 30 min. Glycogen content was also investigated in both pharmacologically induced low plasma NEFA levels fasted rats and pharmacologically induced high plasma NEFA levels fed rats. The participation of Akt and glycogen synthase kinase-3 (GSK-3) in the changes observed was investigated. Plasma levels of NEFA, glucose, and insulin were determined in all conditions. Fasting increased plasma NEFA levels and reduced glycogen content in the liver and skeletal muscles. However, an increase of glycogen content was observed in the heart under this condition. Akt and GSK-3 phosphorylation was reduced during fasting in the liver and skeletal muscles but it remained unchanged in the heart. Our results suggest that in conditions of increased plasma NEFA levels, changes in insulin-stimulated phosphorylation of Akt and GSK-3 and glycogen content vary differently in liver, skeletal muscles, and heart. Akt and GSK-3 phosphorylation and glycogen content are decreased in liver and skeletal Muscles, but in the heart it remain unchanged (Akt and GSK-3 phosphorylation) or increased (glycogen content) due to consistent increase of plasma NEFA levels. Copyright (C) 2009 John Wiley & Sons, Ltd.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofCell Biochemistry and Function
dc.sourceWeb of Science
dc.subjectglucose-fatty acid cycleen
dc.subjectinsulin sensitivityen
dc.subjectfree fatty acidsen
dc.titleChanges of glycogen content in liver, skeletal muscle, and heart from fasted ratsen
dcterms.rightsHolderJohn Wiley & Sons Ltd
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Cruzeiro Sul
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv São Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv Cruzeiro Sul, Inst Phys Act Sci & Sports, Postgrad Program Human Movement Sci, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Phys Educ, Rio Claro, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Phys Educ, Rio Claro, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
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