Spray-dried bacterial cellulose nanofibers: A new generation of pharmaceutical excipient intended for intestinal drug delivery
Nenhuma Miniatura disponível
Data
2020-12-01
Autores
Meneguin, Andreia Bagliotti [UNESP]
Barud, Hernane da Silva
Sabio, Rafael Miguel [UNESP]
Sousa, Paula Zanin de
Manieri, Karyn Fernanda [UNESP]
Pedro de Freitas, Luis Alexandre
Pacheco, Guilherme
Alonso, Jovan Duran
Chorilli, Marlus [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Defibrillation of bacterial cellulose by ultra-refining was efficient to release nanofibers (BCNF) which were spray dried with the matrices formers mannitol (MN), maltodextrin or hydroxypropylmethylcellulose. The best microsystem comprised the association of BCNF and MN, so the selected microparticles were loaded with diclofenac sodium or caffeine. Depending on the proportion of BCNF, the nanofibers collapse promoted by spray drying can occur onto surface or into microparticles core, leading to different release behaviors. Samples showed pH-dependent drug release, so the microsystem developed with the lowest BCNF concentration showed important trend to gastroresistance. Caffeine was spray dried as a free drug and for this reason it was devoid of any control over release rates. The set of results showed BCNF can be considered an interesting and potential pharmaceutical excipient for lipophilic drugs. Beyond that, BCNF association with MN can lead to novel enteric drug delivery systems based on natural polymers.
Descrição
Palavras-chave
Intestinal drug delivery, Pharmaceutical excipients, Bacterial cellulose nanofibers, Spray drying
Como citar
Carbohydrate Polymers. Oxford: Elsevier Sci Ltd, v. 249, 13 p., 2020.