Now showing items 1-10 of 22
Analysis of gene silencing mechanisms in laryngeal squamous cell carcinoma
(International Journal of Molecular Medicine, 2009-01-01) [Artigo]
Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas
(Cancer Genetics and Cytogenetics, 2004-04-01) [Artigo]
Head and neck squamous cell carcinoma is a disease associated with tobacco and alcohol abuse. There is evidence that the oncogenic human papillomavirus (HPV) may also be a risk for upper aerodigestive tract cancers. High-risk ...
Analysis of CDKN1A polymorphisms: markers of cancer susceptibility?
(Cancer Genetics and Cytogenetics, 2003-04-15) [Artigo]
The CDKN1A (TP21)(2) gene encodes a 21-kD protein that is a critical downstream mediator of wild-type TP53 and an important regulator of the cell cycle. Failure in the function of this gene would be expected to result in ...
Epigenetic Silencing of CRABP2 and MX1 in Head and Neck Tumors
(Neoplasia, 2009-12-01) [Artigo]
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease affecting the epithelium of the oral cavity, pharynx and larynx. Conditions of most patients are diagnosed at late stages of the disease, and no ...
Differential transcription of ribosomal cistrons denoting nucleolar dominance in hybrids of Drosophila mulleri and Drosophila navojoa (mulleri complex, Repleta group)
(Genetics and Molecular Biology, 2007-01-01) [Artigo]
The fruit flies Drosophila mulleri and Drosophila navojoa are included in the mulleri complex of the mulleri subgroup and Repleta group. Although there is no demonstration that interspecific crosses between them occur in ...
Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma
(Oncology Reports, 2009-03-01) [Artigo]
Laryngeal squamous cell carcinoma is very common in head and neck cancer, with high mortality rates and poor prognosis. In this study, we compared expression profiles of clinical samples from 13 larynx tumors and 10 ...
The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
(Proceedings of the National Academy of Sciences of the United States of America, 2003-11-11) [Artigo]
Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the ...
HFE gene mutations in Brazilian thalassemic patients
(Brazilian Journal of Medical and Biological Research, 2006-12-01) [Artigo]
Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron intake and progressive storage and is related to mutations in the HFE gene. Interactions between thalassemia and hemochromatosis ...
Identification of human chromosome 22 transcribed sequences with ORF expressed sequence tags
(Proceedings of the National Academy of Sciences of the United States of America, 2000-11-07) [Artigo]
Transcribed sequences in the human genome can be identified with confidence only by alignment with sequences derived from cDNAs synthesized from naturally occurring mRNAs. We constructed a set of 250,000 cDNAs that represent ...
Molecular models of NS3 protease variants of the Hepatitis C virus
(Bmc Structural Biology, 2005-01-21) [Artigo]
Background: Hepatitis C virus (HCV) currently infects approximately three percent of the world population. In view of the lack of vaccines against HCV, there is an urgent need for an efficient treatment of the disease by ...