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Ac2-26 mimetic peptide of annexin A1 inhibits local and systemic inflammatory processes induced by bothrops moojeni venom and the lys-49 phospholipase A2 in a rat model
(Plos One, 2015) [Artigo]
Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein that modulates anti-inflammatory process and its therapeutic potential has recently been recognized in a range of systemic inflammatory disorders. The ...
Differences in transcriptional activity of human papillomavirus type 6 molecular variants in recurrent respiratory papillomatosis
(Plos One, 2015) [Artigo]
A significant proportion of recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus type 6 (HPV-6). The long control region (LCR) contains cis-elements for regulation of transcription. Our aim was to ...
Influence of functional polymorphisms in TNF-α, IL-8, and IL-10 cytokine genes on mRNA expression levels and risk of gastric cancer
(Tumour Biology : The Journal Of The International Society For Oncodevelopmental Biology And Medicine, 2015) [Artigo]
Functional polymorphisms in promoter regions can produce changes in the affinity of transcription factors, thus altering the messenger ribonucleic acid (mRNA) expression levels of inflammatory cytokines associated with the ...
The effects of temperature and busulfan (Myleran) on the yellowtail tetra Astyanax altiparanae (Pisces, Characiformes) spermatogenesis
(Theriogenology, 2015-10-01) [Artigo]
We aimed to standardize a protocol to suppress spermatogenesis in the characiform fish, Astyanax altiparanae, for future use as a host in germ cell transplant research, opening opportunities for a range of studies, such ...
Oogenesis in Laetacara araguaiae (Ottoni and Costa, 2009) (Labriformes: Cichlidae)
(Zygote (cambridge, England), 2015-09-09) [Artigo]
We aimed to analyze the oogenesis of adult females of the cichlid fish Laetacara araguaiae. The specimens' gonads were removed and processed for light and transmission electron microscopy. Oogenesis in L. araguaiae showed ...
Protective effects of the galectin-1 protein on in vivo and in vitro models of ocular inflammation
(Molecular Vision, 2015) [Artigo]
Galectin-1 (Gal-1) is a β-galactoside-binding protein with diverse biological activities in the pathogenesis of inflammation but has been poorly investigated in terms of ocular inflammation. In the present study, we monitored ...
ANXA1Ac₂₋₂₆ peptide reduces ID1 expression in cervical carcinoma cultures
(Gene, 2015-10-10) [Artigo]
Cervical cancer is the second most frequent cancer in women worldwide and is associated with genetic alterations, infection with human papilloma virus (HPV), angiogenesis and inflammatory processes. The idea that inflammation ...
Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis
(Revista Brasileira De Hematologia E Hemoterapia, 2015) [Artigo]
This review discusses hemoglobin D-Punjab, also known as hemoglobin D-Los Angeles, one of the most common hemoglobin variants worldwide. It is derived from a point mutation in the beta-globin gene (HBB: c.364G>C; rs33946267) ...
MMP-2 and TIMP-2 in male and female prostates of mongolian gerbil: effects of hormonal manipulation
(Histology and Histopathology, 2011) [Artigo]
TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 ...
Transposition burst of mariner-like elements in the sequenced genome of Rhodnius prolixus
(Insect Biochemistry And Molecular Biology, 2015-09-09) [Artigo]
Transposable elements (TEs) are widespread in insect´s genomes. However, there are wide differences in the proportion of the total DNA content occupied by these repetitive sequences in different species. We have analyzed ...