Now showing items 1-3 of 3
Genetic and biochemical markers of hydroxyurea therapeutic response in sickle cell anemia
(Bmc Medical Genetics, 2013-10-09) [Artigo]
Background: Sickle cell anemia (SCA) presents a complex pathophysiology which can be affected by a number of modifying factors, including genetic and biochemical ones. In Brazil, there have been no studies verifying ...
Impact of genetic polymorphisms in key enzymes of homocysteine metabolism on the pathophysiology of sickle cell anemia
(Free Radical Biology And Medicine, 2017-05-01) [Artigo]
This work aimed at studying a possible influence of methylenetetrahydrofolate reductase (MTHFR; C. 677C > T) and cystathionine beta-synthase (CBS; 844ins68) polymorphisms on overall oxidative status of sickle cell anemia ...
The influence of hydroxyurea on oxidative stress in sickle cell anemia
(Revista Brasileira de Hematologia e Hemoterapia, 2012-01-01) [Artigo]
OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any ...