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dc.contributor.authorBiancardi, Manoel F.
dc.contributor.authorPerez, Ana P. S.
dc.contributor.authorGoes, Rejane M. [UNESP]
dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.authorVilamaior, Patricia S. L.
dc.contributor.authorTaboga, Sebastiao R. [UNESP]
dc.identifier.citationExperimental Biology and Medicine. London: Royal Soc Medicine Press Ltd, v. 237, n. 11, p. 1298-1309, 2012.
dc.description.abstractThe development of the prostate depends on a precise androgenic control, so sensible interferences may predispose this gland to develop prostatic diseases during life. These aspects are of interest and preoccupation, since human beings are exposed to a growing number of endocrine-disrupting chemicals with androgenic potential. Therefore, our aim was to evaluate the prostates of adult gerbils exposed to testosterone during intrauterine life. Serological, morphological, morphometric-stereologic, immunohistochemical and three-dimensional reconstruction analyses were used. We found that the testosterone effects were dose-dependent and more harmful to females, leading to the development of masculine characteristics, evidenced by an increased anogenital distance, and absence of vaginal opening and the ectopic development of prostatic tissue. Moreover, premalignant lesions, such as prostatic intraepithelial neoplasia, were observed in addition to inflammatory foci in the prostate. The results showed that the prenatal exposure to testosterone may affect the reproductive system, disrupting developmental processes and increasing susceptibility to the development of prostatic diseases in the Mongolian gerbil.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherRoyal Soc Medicine Press Ltd
dc.relation.ispartofExperimental Biology and Medicine
dc.sourceWeb of Science
dc.subjectendocrine-disrupting chemicalsen
dc.titlePrenatal testosterone exposure as a model for the study of endocrine-disrupting chemicals on the gerbil prostateen
dcterms.rightsHolderRoyal Soc Medicine Press Ltd
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionRio Preto Univ Ctr UNIRP
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13084864 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, IBILCE, Dept Biol, Lab Microscopy & Microanal,UNESP, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Morphol, BR-74001970 Goiania, Go, Brazil
dc.description.affiliationRio Preto Univ Ctr UNIRP, Biol Sci & Vet Med Sch, BR-15025400 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, IBILCE, Dept Biol, Lab Microscopy & Microanal,UNESP, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 07/06862-3
dc.description.sponsorshipIdCNPq: 301111/05-7
dc.description.sponsorshipIdCNPq: 473626/2010-1
dc.description.sponsorshipIdCNPq: 300163/2008-8
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