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dc.contributor.authorManoel-Caetano, Fernanda da Silva [UNESP]
dc.contributor.authorAparecida Carareto, Claudia Marcia [UNESP]
dc.contributor.authorBorim, Aldenis Albaneze
dc.contributor.authorMiyazaki, Kenji
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.identifier.citationTransactions of The Royal Society of Tropical Medicine and Hygiene. New York: Elsevier B.V., v. 102, n. 11, p. 1102-1107, 2008.
dc.description.abstractTrypanosoma cruzi presents a high degree of intraspecific variability, with possible implications for the pathogenesis of Chagas disease. The aim of this study was to evaluate T cruzi kDNA minicircle gene signatures using the low-stringency single-specific-primer PCR technique in both peripheral blood and oesophageal. mucosa from chronic chagasic patients, with or without megaesophagus, atone or in combination with cardiopathy and megacolon. It was not possible to identify a uniform pattern of shared bands between blood and oesophageal mucosa samples from individuals with the same clinical. form or mixed forms, suggesting multiple T. cruzi infections with differential tissue tropism. Thus, the results indicate that there is an intense intraspecific variability in the hypervariable regions of T cruzi kDNA, which has so far made it impossible to correlate the genetic profile of this structure with the clinical manifestations of Chagas disease. (C) 2008 Royal. Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. AIL rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.sourceWeb of Science
dc.subjectChagas diseaseen
dc.subjectTrypanosoma cruzien
dc.subjectkDNA minicirclesen
dc.subjectGenetic variabilityen
dc.titlekDNA gene signatures of Trypanosoma cruzi in blood and oesophageal mucosa from chronic chagasic patientsen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSch Med
dc.contributor.institutionHosp Base
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationSch Med, FAMERP, Dept Surg, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationHosp Base, Serv Endoscopy, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Biol, Sao Jose do Rio Preto, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt[5][5]
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