Os agentes de desinfecção de próteses influenciam a rugosidade de superfície e a adesão/formação de biofilme de Candida albicans em resina acrílica?: revisão sistemática e meta-análise
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Data
2021-08-02
Autores
Ferro, Amanda Costa
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Objetivo: Este estudo tem como objetivo revisar sistematicamente a literatura sobre a influência dos agentes de desinfecção na rugosidade e na adesão e formação de biofilme em resinas acrílicas para base de prótese. Métodos: O protocolo da revisão sistemática foi registrado na plataforma International platform of registered systematic review and meta-analysis protocols (INPLASY: INPLASY202120039) e o Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist (PRISMA) foi utilizado para o relato do estudo. Considerou-se o acrônimo PICO da seguinte forma: (P) Amostras de resina acrílica termopolimerizável para base de prótese; (I) Agentes de desinfecção química de próteses; (C) Água destilada ou PBS (Tampão fosfato-salino) e (O) Rugosidade de superfície; Adesão e formação de biofilme de Candida albicans. Foi utilizada uma estratégia de busca nas bases de dados PubMed/MEDLINE, Embase, Scopus, Web of Science e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Biblioteca Brasileira em Odontologia (BBO), e busca na literatura cinzenta. Foram incluídos estudos in vitro que avaliaram os efeitos dos agentes de desinfecção química por imersão, na rugosidade de superfície (µm) e na atividade antimicrobiana por contagem de unidades formadoras de colônia (UFC/mL) em amostras de resina acrílica termopolimerizável para base de próteses. Para a avaliação do risco de viés dos estudos incluídos, a ferramenta OHAT foi adaptada e utilizada. A síntese dos dados foi feita de forma qualitativa para os desfechos de interesse, e quantitativa, através da meta-análise, para a rugosidade de superfície. Resultados: Após a remoção de duplicatas a busca nas bases de dados e manualmente em listas de referências resultou em 2291 estudos. Após a triagem inicial por títulos e resumos, 2119 foram excluídos. Assim, 172 estudos foram lidos na íntegra para verificar se atendiam aos critérios de elegibilidade. Dentre eles, 155 foram excluídos pelos critérios de exclusão, tendo sido incluídos 17 estudos. Após análise do risco de viés, somente 9 estudos foram incluídos na meta-análise. Os resultados da meta-análise mostraram que as soluções avaliadas (hipoclorito de sódio 0,5%, hipoclorito de sódio 1%, peróxido alcalino e alguns extratos) não influenciaram a rugosidade das amostras de resina acrílica para base de próteses. Além disso, na análise qualitativa, não foi possível estabelecer uma associação entre a rugosidade e a adesão e formação de biofilme de Candida albicans sobre as amostras de resina acrílica termopolimerizável. Conclusão: Diante das limitações do estudo, concluiu-se que os agentes de desinfecção não influenciaram a rugosidade de superfície de resinas acrílicas para base de próteses.
Objective: A systematic review of the literature was conducted to evaluate the influence of denture cleansers on roughness and adhesion and biofilm formation in denture base acrylic resins. Methods: The review protocol was registered on the International platform of registered systematic review and meta-analysis protocols (INPLASY: INPLASY202120039) and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist (PRISMA) was used for the study report. The acronym PICO was considered as follows: (P) Denture base acrylic resin samples; (I) Chemical denture cleansers; (C) Distilled water or Phosphate buffered saline (PBS) and (O) Surface roughness; Candida albicans adhesion and biofilm formation. A search strategy was used in the PubMed/MEDLINE, Embase, Scopus, Web of Science and Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Biblioteca Brasileira em Odontologia (BBO) databases and gray literature search. In vitro studies that evaluated the effects of denture cleansers immersion on surface roughness (µm) and antimicrobial activity by counting colony-forming units (CFU/mL) in samples of heat-polymerized denture base acrylic resins were included. The OHAT tool was adapted to assess the risk of bias of the included studies. Qualitative data synthesis was performed for the outcomes, and quantitative, through meta-analysis, for surface roughness. Results: After removing duplicates, the search in databases and manually in reference lists resulted in 2291 studies. After initial screening by titles and abstracts, 2119 were excluded. Thus, 172 studies were fully readed to verify if they met the eligibility criteria. Then, 155 were excluded by the exclusion criterias, and 17 studies were included. After the assessed risk of bias, only 9 studies were included in the meta-analysis. The meta-analysis results showed that the evaluated solutions (0.5% sodium hypochlorite, 1% sodium hypochlorite, alkaline peroxide and some extracts) did not influence the roughness of denture base acrylic resin samples. Furthermore, in the qualitative analysis, it was not possible to confirm an association between roughness and Candida albicans adhesion and biofilm formation on the acrylic resin samples. Conclusion: Whitin the limitations of the study, it was concluded that denture cleansers did not influence the surface roughness of denture base acrylic resins.
Objective: A systematic review of the literature was conducted to evaluate the influence of denture cleansers on roughness and adhesion and biofilm formation in denture base acrylic resins. Methods: The review protocol was registered on the International platform of registered systematic review and meta-analysis protocols (INPLASY: INPLASY202120039) and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist (PRISMA) was used for the study report. The acronym PICO was considered as follows: (P) Denture base acrylic resin samples; (I) Chemical denture cleansers; (C) Distilled water or Phosphate buffered saline (PBS) and (O) Surface roughness; Candida albicans adhesion and biofilm formation. A search strategy was used in the PubMed/MEDLINE, Embase, Scopus, Web of Science and Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Biblioteca Brasileira em Odontologia (BBO) databases and gray literature search. In vitro studies that evaluated the effects of denture cleansers immersion on surface roughness (µm) and antimicrobial activity by counting colony-forming units (CFU/mL) in samples of heat-polymerized denture base acrylic resins were included. The OHAT tool was adapted to assess the risk of bias of the included studies. Qualitative data synthesis was performed for the outcomes, and quantitative, through meta-analysis, for surface roughness. Results: After removing duplicates, the search in databases and manually in reference lists resulted in 2291 studies. After initial screening by titles and abstracts, 2119 were excluded. Thus, 172 studies were fully readed to verify if they met the eligibility criteria. Then, 155 were excluded by the exclusion criterias, and 17 studies were included. After the assessed risk of bias, only 9 studies were included in the meta-analysis. The meta-analysis results showed that the evaluated solutions (0.5% sodium hypochlorite, 1% sodium hypochlorite, alkaline peroxide and some extracts) did not influence the roughness of denture base acrylic resin samples. Furthermore, in the qualitative analysis, it was not possible to confirm an association between roughness and Candida albicans adhesion and biofilm formation on the acrylic resin samples. Conclusion: Whitin the limitations of the study, it was concluded that denture cleansers did not influence the surface roughness of denture base acrylic resins.
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Palavras-chave
Candida albicans, Estomatite sob prótese, Bases de dentadura, Propriedades de superfície, Resinas acrílicas, Higienizadores de dentadura, Candida albicans, Stomatitis, Denture, Denture bases, Surface properties, Acrylic resins, . Denture cleansers.