RSS 1.0Departamento de Física
Browse by
Recent Submissions
-
Disturbing Lipid Phase Equilibrium in Model Membrane Induced by Lytic Peptides
Alvares, Dayane S.
; Ruggiero Neto, João (Brazilian Journal of Physics, 2022) [Artigo]
Lytic peptides are rich in cationic and hydrophobic residues that form amphipathic α-helix when in contact with lipid bilayers. Evidence showed that they act on the lipidic phase of the cell membranes, inserting into the ... -
Small Neutral Crowding Solute Effects on Protein Folding Thermodynamic Stability and Kinetics
Contessoto, Vinícius G.; ; Chahine, Jorge ; Leite, Vitor B. P. ; (Journal of Physical Chemistry B, 2021) [Artigo]
Molecular crowding is a ubiquitous phenomenon in biological systems, with significant consequences on protein folding and stability. Small compounds, such as the osmolyte trimethylamineN-oxide (TMAO), can also present ... -
A protective vaccine against the toxic activities following Brown spider accidents based on recombinant mutated phospholipases D as antigens
; ; ; ; ; ; ; ; Minozzo, João Carlos; Mariutti, Ricardo Barros et al. (International Journal of Biological Macromolecules, 2021) [Artigo]
Accidents involving Brown spiders are reported throughout the world. In the venom, the major toxins involved in the deleterious effects are phospholipases D (PLDs). In this work, recombinant mutated phospholipases D from ... -
Potential curve for a Helium dimer confined by prolate spheroidal boxes
Batael, Hugo de Oliveira; Drigo Filho, Elso (European Physical Journal D, 2021) [Artigo]
Abstract: The potential curve for a confined He 2 dimer is computed using the variational method. The approach proposed here uses a trial function for the ground state composed of the Slater determinant with the orbitals ... -
Metallo-stannosilicates as inorganic supports to immobilization of lipase from Thermomyces lanuginosus for biodiesel production
Da Silva, Danilo Antonio; De Vasconcellos, Adriano ; Nery, José Geraldo (Ecletica Quimica, 2021) [Artigo]
This study reports the application of metallo-stannosilicates as potential inorganic solid matrixes for enzymes immobilization and their use as a heterogenous catalysts in enzymatic transesterification reactions for the ... -
Numerical determination of the order of phase transitions in Ising systems with multispin interactions
; Chahine, Jorge; (Physical Review B, 1991) [Artigo]
The method of the fourth-order cumulant of Challa, Landau, and Binder is used together with the Monte Carlo histogram technique of Ferrenberg and Swendsen to study the order of the phase transitions of two-dimensional Ising ... -
Water regulation of actinomycin-D binding to DNA: The interplay among drug affinity, DNA long-range conformation, and hydration
Neto, João Ruggiero; Colombo, Marcio Francisco (Biopolymers, 2000) [Artigo]
Actinomycin-D (actD) binds to natural DNA at two different classes of binding sites, weak and strong. The affinity for these sites is highly dependent on DNA sequence and solution conditions, and the interaction appears ... -
Supersymmetric Quantum Mechanics and Partially Solvable Potential
Drigo Filho, E.; Ricotta, R. M. (Physics of Atomic Nuclei, 1998) [Artigo]
Supersymmetric quantum mechanics can be used to obtain the spectrum and eigenstates of one-dimensional Hamiltonians. It is particularly useful when applied to partially solvable potentials because a superalgebra allows us ... -
Photoconductivity spectra of polymeric devices using poli(pphenylene vinylene) (PPV) derivatives as the active layer
(Proceedings - International Symposium on Electrets, 2008) [Trabalho apresentado em evento] -
Microscopical aspects of accessory air breathing through a modified stomach in the armoured catfish Liposarcus anisitsi (Siluriformes, Loricariidae)
(Cytobios, 2001) [Artigo]The presence of an accessory air breathing mechanism as verified by several authors, is widespread among Loricariidae, where modified parts of the digestive tract act primarily as oxygen-exchange organs. An anatomical and ... -
A Method for Detection of Water Permeation Events in Molecular Dynamics Simulations of Lipid Bilayers
Camilo, Carlos Roberto de Souza; Ruggiero, José Roberto ; de Araujo, Alexandre Suman (Brazilian Journal of Physics, 2022) [Artigo]
The cell membrane is one of the most important structures of life. Understanding its functioning is essential for several human knowledge areas, mainly how it controls the efflux of substances between the cytoplasm and the ... -
Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi
; ; Hernandez-Alvarez, Lilian; ; ; ; ; ; ; (Journal of Medicinal Chemistry, 2022) [Artigo]
Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively inhibits cathepsin L-like cysteine proteases. We evaluated the potency of gallinamide A and 23 synthetic analogues against intracellular ... -
Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70
; ; ; ; ; Zazeri, Gabriel; Povinelli, Ana P. R. ; ; ; et al. (Molecules, 2022) [Artigo]
Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like ... -
Examining the Ensembles of Amyloid-β Monomer Variants and Their Propensities to Form Fibers Using an Energy Landscape Visualization Method
Sanches, Murilo N.; ; ; ; ; Leite, Vitor B. P. (Journal of Physical Chemistry B, 2022) [Artigo]
The amyloid-β (Aβ) monomer, an intrinsically disordered peptide, is produced by the cleavage of the amyloid precursor protein, leading to Aβ-40 and Aβ-42 as major products. These two isoforms generate pathological aggregates, ... -
Tetracycline Derivatives Inhibit Plasmodial Cysteine Protease Falcipain-2 through Binding to a Distal Allosteric Site
Hernández González, Jorge Enrique; ; ; ; ; (Journal of Chemical Information and Modeling, 2022) [Artigo]
Allosteric inhibitors regulate enzyme activity from remote and usually specific pockets. As they promise an avenue for less toxic and safer drugs, the identification and characterization of allosteric inhibitors has gained ... -
Adsorption of lysozyme into a charged confining pore
; ; ; de Carvalho, Sidney J. (Physical Chemistry Chemical Physics, 2021) [Artigo]
Several applications arise from the confinement of proteins on surfaces because their stability and biological activity are enhanced. It is also known that the way in which a protein adsorbs on the surface is important for ... -
Natural plant fibers obtained from agricultural residue used as an ingredient in food matrixes or packaging materials: A review
; ; ; Canizares, Diego; (Comprehensive Reviews in Food Science and Food Safety, 2022) [Resenha]
Every year, agrifood activities generate a large amount of plant byproducts, which have a low economical value. However, the valorization of these byproducts can contribute to increasing the intake of dietary fibers and ... -
Unravelling the interaction of piperlongumine with the nucleotide-binding domain of hsp70: A spectroscopic and in silico study
Povinelli, Ana Paula Ribeiro; Zazeri, Gabriel ; ; Cornélio, Marinônio Lopes (Pharmaceuticals, 2021) [Artigo]
Piperlongumine (PPL) is an alkaloid extracted from several pepper species that exhibits anti-inflammatory and anti-carcinogenic properties. Nevertheless, the molecular mode of action of PPL that confers such powerful ... -
Searching for drug leads targeted to the hydrophobic cleft of dengue virus capsid protein
; Caruso, Ícaro P.; ; ; ; ; ; (Journal of Enzyme Inhibition and Medicinal Chemistry, 2022) [Artigo]
We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of ... -
Quercetin induces lipid domain-dependent permeability
Leite, Natália Bueno; Martins, Danubia Batista ; Alvares, Dayane S. ; Cabrera, Marcia Perez dos Santos (Chemistry and Physics of Lipids, 2022) [Artigo]
Quercetin is a polyphenolic molecule with a broad spectrum of biological activities derived from its antioxidant property. Its mechanism of action has been explained by its binding and/or interference with enzymes, receptors, ...