Now showing items 1-10 of 10
Crystallization and preliminary X-ray diffraction analysis of a novel sphingomyelinase D from Loxosceles gaucho venom
(Acta Crystallographica Section F-structural Biology Communications, 2014-10-01) [Artigo]
Brown spider envenomation results in dermonecrosis, intravascular coagulation, haemolysis and renal failure, mainly owing to the action of sphingomyelinases D (SMases D), which catalyze the hydrolysis of sphingomyelin to ...
Crystallization and preliminary X-ray diffraction studies of an L-amino-acid oxidase from Lachesis muta venom
(Acta Crystallographica Section F-structural Biology Communications, 2014-11-01) [Artigo]
Snake-venom proteins form multi-component defence systems by the recruitment and rapid evolution of nonvenomous proteins and hence serve as model systems to understand the structural modifications that result in toxicity. ...
Crystal structure of mature 2S albumin from Moringa oleifera seeds
(Biochemical And Biophysical Research Communications, 2015-10-23) [Artigo]
2S albumins, the seed storage proteins, are the primary sources of carbon and nitrogen and are involved in plant defense. The mature form of Moringa oleifera (M. oleifera), a chitin binding protein isoform 3-1 (mMo-CBP3-1) ...
Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom
(Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2011-02-01) [Artigo]
Phospholipases D are the major dermonecrotic component of Loxosceles venom and catalyze the hydrolysis of phospholipids, resulting in the formation of lipid mediators such as ceramide-1-phosphate and lysophosphatidic acid ...
Purification, crystallization and preliminary X-ray diffraction analysis of a class P-III metalloproteinase (BmMP-III) from the venom of Bothrops moojeni
(Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2012-10-01) [Artigo]
Snake-venom metalloproteinases (SVMPs) comprise a family of haemostatically active toxins which can cause haemorrhage, coagulopathy, inhibition of platelet aggregation and inflammatory response. These effects are attributed ...
Modeling and molecular dynamics indicate that snake venom phospholipase B-like enzymes are Ntn-hydrolases
(Toxicon, 2018-10-01) [Resenha]
Phospholipase-B-like (SVPLB-like) enzymes are present in relatively small amounts in a number of venoms, however, their biological function and mechanisms of action are un-clear. A three-dimensional model of the SVPLB-like ...
Active site mapping of Loxosceles phospholipases D: biochemical and biological features
(Faseb Journal, 2016-04-01) [Resumo]
Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins
(Toxicon, 2014-06-01) [Artigo]
The Loxosceles genus spiders (the brown spiders) are encountered in all the continents, and the clinical manifestations following spider bites include skin necrosis with gravitational lesion spreading and occasional systemic ...
Zika virus NS2B/NS3 proteinase: A new target for an old drug - Suramin a lead compound for NS2B/NS3 proteinase inhibition-
(Antiviral Research, 2018-12-01) [Artigo]
Zika virus infection is the focus of much research due to the medical and social repercussions. Due the role of the viral NS2B/NS3 proteinase in maturation of the viral proteins, it had become an attractive antiviral target. ...
Chemical and thermal influence of the [4Fe-4S](2+) cluster of A/G-specific adenine glycosylase from Corynebacterium pseudotuberculosis
(Biochimica Et Biophysica Acta-general Subjects, 2015-02-01) [Artigo]
The gram-positive bacteria Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis in livestock significantly reduces productivity and often causes death. The adenine/guanine-specific DNA glycosylase ...