Now showing items 1-5 of 5
Molecular models of cyclin-dependent kinase 1 complexed with inhibitors
(Biochemical and Biophysical Research Communications, 2004-11-12) [Artigo]
Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). The structures of CDK2 complexed with roscovitine and deschoroflavopiridol have been reported, however no ...
Structures of human purine nucleoside phosphorylase complexed with inosine and ddI
(Biochemical and Biophysical Research Communications, 2004-01-23) [Artigo]
Human purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent ...
Molecular models for shikimate pathway enzymes of Xylella fastidiosa
(Biochemical and Biophysical Research Communications, 2004-07-30) [Artigo]
The Xylella fastidiosa is a bacterium that is the cause of citrus variegated chlorosis (CVC). The shikimate pathway is of pivotal importance for production of a plethora of aromatic compounds in plants, bacteria, and fungi. ...
Structural bioinformatics study of PNP from Schistosoma mansoni
(Biochemical and Biophysical Research Communications, 2004-09-10) [Artigo]
The parasite Schistosoma mansoni lacks the de novo pathway for purine biosynthesis and depends on salvage pathways for its purine requirements. Schistosomiasis is endemic in 76 countries and territories and amongst the ...
Interaction of shikimic acid with shikimate kinase (Retracted Article. See vol 334, pg 967, 2005)
(Biochemical and Biophysical Research Communications, 2004-12-03) [Artigo]
The crystal structure of shikimate kinase from Mycobacterium tuberculosis (MtSK) complexed with MgADP and shikimic acid (shikimate) has been determined at 2.3 Angstrom resolution, clearly revealing the amino acid residues ...