Now showing items 1-4 of 4
Molecular models of protein targets from Mycobacterium tuberculosis
(Journal of Molecular Modeling, 2005-03-01) [Artigo]
Structural characterization of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design since some of these proteins may be present in the bacterial genome, but absent in humans. ...
New catalytic mechanism for human purine nucleoside phosphorylase
(Biochemical and Biophysical Research Communications, 2005-02-18) [Artigo]
Human purine nucleoside phosphorylase has been submitted to intensive structure-based design of inhibitors, most of them using low-resolution structures of human PNP. Recently, several structures of human PNP have been ...
Crystal structure of human PNP complexed with hypoxanthine and sulfate ion
(Biochemical and Biophysical Research Communications, 2005-01-14) [Artigo]
Purine nucleoside phosphorylase (PNP) is a ubiquitous enzyme, which plays a key role in the purine salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects ...
Structural Basis for Interaction of Inhibitors with Cyclin-Dependent Kinase 2
(Current Computer-aided Drug Design, 2005-01-01) [Artigo]
Cell cycle progression is tightly controlled by the activity of cyclin-dependent kinases (CDKs). CDKs are inactive as monomers, and activation requires binding to cyclins, a diverse family of proteins whose levels oscillate ...