Synthesis and Characterization of Novel, Highly Crystalline Poly(vinyl alcohol) Microspheres for Chemoembolization Therapy
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Data
2011-08-05
Autores
Semenzim, Vinicius Ladeia [UNESP]
Basso, Glaucia Grazielli [UNESP]
Silva, Danilo Antonio da [UNESP]
Vasconcellos, Adriano de [UNESP]
Agreli, Guilherme
Marques Lima-Oliveira, Ana Paula
Kawasaki-Oyama, Rosa Sayoko
Braile, Domingo Marcolino
Nery, Jose Geraldo [UNESP]
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Wiley-Blackwell
Resumo
Biodegradable polymeric microspheres can be used to deliver drugs through controlled rate and targeted processes. The drug is released from the particles by drug leaching or degradation of the polymeric matrix. Crystallinity can play a very important role in the degradation of polymeric matrixes; it can affect the drug-release rate, especially in chemoembolization. Most commercial embolic agents have a low degree of crystallinity, and the correlation between the drug-delivery rate and the degree of crystallinity is not fully understood. This study presents the appropriated synthesis conditions for the preparation of highly crystalline poly(vinyl alcohol) and poly(vinyl alcohol)/poly(vinyl acetate) microspheres and physicochemical characterizations by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and cross-polarization/magic angle spinning nuclear magnetic resonance. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 1417-1423, 2011
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biomaterials, NMR, synthesis, X-ray
Como citar
Journal of Applied Polymer Science. Hoboken: Wiley-blackwell, v. 121, n. 3, p. 1417-1423, 2011.