Exibir registro simples

dc.contributor.authorRocha, L.F.O. [UNESP]
dc.contributor.authorTarragó Pinto, M.E.
dc.contributor.authorCaliri, A.
dc.date.accessioned2014-05-20T14:02:48Z
dc.date.available2014-05-20T14:02:48Z
dc.date.issued2004-03-01
dc.identifierhttp://dx.doi.org/10.1590/S0103-97332004000100013
dc.identifier.citationBrazilian Journal of Physics. Sociedade Brasileira de Física, v. 34, n. 1, p. 90-101, 2004.
dc.identifier.issn0103-9733
dc.identifier.urihttp://hdl.handle.net/11449/22121
dc.description.abstractGlobular proteins are produced as a linear chain of aminoacids in water solution in the cell and, in the same aqueous environment, fold into their respective unique and functional native structures. In spite of this, many theoretical studies have tried to explain the folding process in vacuum, but in this paper we adopt an alternative point of view: the folding problem of heteropolymers is analyzed from the solvent perspective. The thermodynamics of the folding process is discussed for a non homogeneous system composed by the chain and solvent together; hydrophobic effects, modulated by the polar/nonpolar attributes of the residue sequence and by its corresponding steric specificities, are proposed as basic ingredients for the mechanisms of the folding process. These ideas are incorporated in both lattice and off-lattice models and treated by Monte Carlo simulations. Configurational and thermodynamical results are compared with properties of real proteins. The results suggest that the folding problem of small globular protein can be considered as a process in which the mechanism to reach the native structure and the requirements for the globule stability are uncoupled.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent90-101
dc.language.isoeng
dc.publisherSociedade Brasileira de Física
dc.relation.ispartofBrazilian Journal of Physics
dc.sourceSciELO
dc.titleThe water factor in the protein-folding problemen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Estadual Paulista IBILCE Departamento de Física
dc.description.affiliationPontifícia Universidade Católica do Rio Grande do Sul Departamento de Física Teórica e Aplicada
dc.description.affiliationUniversidade de São Paulo FCFRP Departamento de Física e Química
dc.description.affiliationUnespUniversidade Estadual Paulista IBILCE Departamento de Física
dc.identifier.doi10.1590/S0103-97332004000100013
dc.identifier.scieloS0103-97332004000100013
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.identifier.fileS0103-97332004000100013.pdf
Localize o texto completo

Arquivos

Thumbnail

Este item aparece nas seguintes coleções

Exibir registro simples