Platinum(II) complexes with carbazates and hydrazides: Synthesis, spectral characterization, computational modeling, and biological studies
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2015-07-02
Autores
Rodrigues, M. A.
Marzano, I. M.
Ribeiro, G. H.
Colina-Vegas, L.
Pivatto, M.
Fontes, A. P.S.
Ribeiro, C. M. [UNESP]
Pavan, F. R. [UNESP]
De Almeida, K. J.
Batista, A. A.
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Resumo
This work reports on the synthesis and characterization of complexes of the type cis-[Pt(L)<inf>2</inf>X<inf>2</inf>], where L = 4-methoxybenzylcarbazate (4-MC), benzyl carbazate (BC), 4-fluorophenoxyacetic acid hydrazide (4-FH), 3-methoxybenzoic acid hydrazide (3-MH), ethyl carbazate (EC), tert-butyl carbazate (TC), (4-hydroxy-phenyl)-acetic acid hydrazide (4-HH), and X = Cl<sup>-</sup> or I<sup>-</sup>. The structures of the platinum(II) complexes were optimized and theoretical data show good agreement with the experimental results, suggesting that the ligands are coordinated via the NH<inf>2</inf> groups. The cytotoxic activity of three representative compounds was evaluated in a chronic myelogenous leukemia cell line and health cell line from mouse (L929). The platinum complex with 4-fluorophenoxyacetic acid hydrazide was more active than the free ligand and carboplatin therefore it may be considered a promising antitumor agent. In addition, the platinum complexes with 4-methoxybenzylcarbazate (4-MC) and benzyl carbazate (BC) exhibited good activity. On the other hand, microbiological assays against Mycobacterium tuberculosis showed that all complexes and organic compounds are not very active.
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Carbazate, Computational modeling, Cytotoxic activity, Hydrazide, Platinum complexes
Como citar
Polyhedron, v. 98, p. 146-153.