Tandem Transesterification–Esterification Reactions Using a Hydrophilic Sulfonated Silica Catalyst for the Synthesis of Wintergreen Oil from Acetylsalicylic Acid Promoted by Microwave Irradiation
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Data
2022-08-01
Autores
Barbosa, Sandro L.
Nelson, David Lee
Freitas, Milton de S.
dos Santos, Wallans Torres Pio
Klein, Stanlei I. [UNESP]
Clososki, Giuliano C.
Caires, Franco J.
Wentz, Alexandre P.
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Resumo
SiO2–SO3H, with a surface area of 115 m2/g and pore volume of 0.38 cm3g−1, and 1.32 mmol H+/g was used as a 20% w/w catalyst for the preparation of methyl salicylate (wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor over 40 min at 120 °C in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be reused three times.
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deacetylation (acyl nucleophilic substitution), green chemistry, methyl salicylate, methylating agent, solid acid catalyst, sulfonated silica catalyst (SiO2–SO3H)
Como citar
Molecules, v. 27, n. 15, 2022.