Now showing items 1-10 of 23
Mutagenic and cytotoxic activity of an isocoumarin (Paepalantine) isolated from Paepalanthus vellozioides
(Teratogenesis Carcinogenesis and Mutagenesis, 1997-01-01) [Artigo]
A new isocoumarin with antimicrobial activity was isolated from Paepalanthus vellozioides (a native Brazilian plant) and called paepalantine. This study was carried out to assess the mutagenic activity of this new agent ...
Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity
(Evidence-based Complementary and Alternative Medicine, 2014-01-01) [Artigo]
Terminalia is a genus of Combretaceous plants widely distributed in tropical and subtropical regions. Thus, the aim of this study was to quantify the majority compounds of the hydroalcoholic extract (7 : 3, v/v) of the ...
Antitumoral, mutagenic and (anti)estrogenic activities of tingenone and pristimerin
(Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy, 2011-11-01) [Artigo]
Cancer constitutes the second main mortality cause in the world, after cardiovascular diseases. In spite of the progresses in the chemotherapeutics treatments, many patients fail chemotherapy, mainly because of side effects ...
Does the gastroprotective action of a medicinal plant ensure healing effects? An integrative study of the biological effects of Serjania marginata Casar. (Sapindaceae) in rats
(Journal Of Ethnopharmacology, 2015-08-22) [Artigo]
Serjania marginata (Sapindaceae), a medicinal plant commonly found in the Brazilian Cerrado, Paraguay, Bolivia and Argentina, is also known as cipó-uva or cipó-timbó. Ethnopharmacological studies indicate that the leaves ...
Quantification of Flavonoids, Naphthopyranones and Xanthones in Eriocaulaceae Species by LC-PDA
(American Journal of Analytical Chemistry, 2012) [Artigo]
The linearity, stability, accuracy and inter-day precisions of the assay method were evaluated in methanolic aerial-part extracts of Paepalanthus giganteus and Syngontnhus nitens from the Eriocaulaceae family. Their small ...
Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens
(Food Chemistry, 2014-07-15) [Artigo]
The antimutagenicity of ten flavonoids, differing in their hydroxylation patterns against direct-acting and indirect-acting mutagens, namely 4-nitro-o-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin ...
Characterization of flavonoids and naphthopyranones in methanol extracts of Paepalanthus chiquitensis herzog by HPLC-ESI-IT-MSn and their mutagenic activity
(Molecules, 2013-01-01) [Artigo]
A HPLC-ESI-IT-MSn method, based on high-performance liquid chromatography coupled to electrospray negative ionization multistage ion trap mass spectrometry, was developed for rapid identification of 24 flavonoid and ...
In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
(Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 2002-01-01) [Artigo]
Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of ...
Evaluation of Estrogenic Potential of Flavonoids Using a Recombinant Yeast Strain and MCF7/BUS Cell Proliferation Assay
(PLOS ONE, 2013-10-01) [Artigo]
Phytoestrogens are of interest because of their reported beneficial effects on many human maladies including cancer, neurodegeneration, cardiovascular disease and diabetes. Furthermore, there is a search for compounds with ...
Serjania marginata Casar extract has no mutagenic effects but induce necrosis in human gastric cancer cells
(Toxicology Letters, 2014-09-10) [Resumo]