Now showing items 1-10 of 25
In vitro cytotoxicity of some natural and semi-synthetic isocoumarins from Paepalanthus bromelioides
(Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 2002-01-01) [Artigo]
Numerous natural compounds have a potential for therapeutic applications, but may have to be chemically modified to alter toxic side effects. We investigated structural parameters that could affect the cytotoxicity of ...
Serjania marginata Casar extract has no mutagenic effects but induce necrosis in human gastric cancer cells
(Toxicology Letters, 2014-09-10) [Resumo]
Characterization and Quantification of the Compounds of the Ethanolic Extract from Caesalpinia ferrea Stem Bark and Evaluation of Their Mutagenic Activity
(Molecules, 2014-10-01) [Artigo]
Caesalpinia ferrea Martius has traditionally been used in Brazil for many medicinal purposes, such as the treatment of bronchitis, diabetes and wounds. Despite its use as a medicinal plant, there is still no data regarding ...
Evaluation of Estrogenic Potential of Flavonoids Using a Recombinant Yeast Strain and MCF7/BUS Cell Proliferation Assay
(PLOS ONE, 2013-10-01) [Artigo]
Phytoestrogens are of interest because of their reported beneficial effects on many human maladies including cancer, neurodegeneration, cardiovascular disease and diabetes. Furthermore, there is a search for compounds with ...
Characterization and Quantification of Compounds in the Hydroalcoholic Extract of the Leaves from Terminalia catappa Linn. (Combretaceae) and Their Mutagenic Activity
(Evidence-based Complementary and Alternative Medicine, 2014-01-01) [Artigo]
Terminalia is a genus of Combretaceous plants widely distributed in tropical and subtropical regions. Thus, the aim of this study was to quantify the majority compounds of the hydroalcoholic extract (7 : 3, v/v) of the ...
Antitumoral, mutagenic and (anti)estrogenic activities of tingenone and pristimerin
(Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy, 2011-11-01) [Artigo]
Cancer constitutes the second main mortality cause in the world, after cardiovascular diseases. In spite of the progresses in the chemotherapeutics treatments, many patients fail chemotherapy, mainly because of side effects ...
Antitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin
(Revista Brasileira de Farmacognosia, 2011-12-01) [Artigo]
Large number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine ...
Anti-Helicobacter pylori activity and oxidative burst inhibition by the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin from Paepalanthus latipes
(Revista Brasileira de Farmacognosia, 2012-02-01) [Artigo]
Helicobacter pylori is a bacterium recognized as the major cause of chronic gastritis and peptic ulcers. Infection by H. pylori induces inflammatory responses and pathological changes in the gastric microenvironment. The ...
Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity
(Evidence-based Complementary and Alternative Medicine, 2011-01-01) [Artigo]
Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), ...
Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test
(Regulatory Toxicology And Pharmacology : Rtp, 2015) [Artigo]
In the neotropical savannah, Astronium species are used in popular medicine to treat allergies, inflammation, diarrhea and ulcers. Given that natural products are promising starting points for the discovery of novel ...