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No dia 25 de Setembro de 2023, faremos a migração do Repositório Institucional para a versão 7.6 do sistema DSpace. Por este motivo, o Repositório Institucional ficará indisponível neste dia. Contamos com a compreensão de todos.
Departamento de Bioquímica e Tecnologia
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The Dimeric Peptide (KKYRYHLKPF)2K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection
Ayusso, Gabriela Miranda
; Lima, Maria Letícia Duarte ; da Silva Sanches, Paulo Ricardo ; ; Martins, Daniel Oliveira Silva ; da Conceição, Pâmela Jóyce Previdelli ; Carvalho, Tamara ; da Costa, Vivaldo Gomes ; Bittar, Cíntia ; et al. (Viruses, 2023) [Artigo]
Chikungunya virus (CHIKV) and Zika virus (ZIKV) are important disease-causing agents worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these viruses. However, peptides have shown great potential ... -
Adsorption of Cadmium(II) Ions from Aqueous Solutions Using Calcium Molybdate
; ; ; ; ; Longo, Elson (Materials Science Forum, 2022) [Capítulo de livro]
The presence of toxic metals in aquatic environments poses serious problems for ecosystems and especially for human health. Numerous types of metal oxides have been used to remove these metals and other toxic organic ... -
Efficacy of the combination of P5 peptide and photodynamic therapy mediated by bixin and chlorin-e6 against Cutibacterium acnes biofilm
Pereira, Felipe; de Annunzio, Sarah Raquel ; ; ; Cilli, Eduardo Maffud ; Barbugli, Paula Aboud ; Fontana, Carla Raquel (Photodiagnosis and Photodynamic Therapy, 2022) [Artigo]
In this study, the action of antimicrobial peptide (AMP) P5 and antimicrobial photodynamic therapy (aPDT) mediated by bixin and chlorin-e6 (Ce6) on Cutibacterium acnes (C. acnes) in planktonic phase and biofilm were evaluated ... -
Singular impasse points of planar constrained differential systems
Perez, Otavio Henrique; da Silva, Paulo Ricardo (Bulletin of the Belgian Mathematical Society - Simon Stevin, 2022) [Artigo]
Planar analytic constrained differential systems (or impasse systems) are given by (Formular Presented) where F is a vector field and A is a matrix valued function. This class of systems differs from classical ODE’s due ... -
Adiponectin reverses β-Cell damage and impaired insulin secretion induced by obesity
; ; ; ; ; Mosele, Francielle C.; Felisbino, Sergio L. ; ; (Aging Cell, 2023) [Artigo]
Obesity significantly decreases life expectancy and increases the incidence of age-related dysfunctions, including β-cell dysregulation leading to inadequate insulin secretion. Here, we show that diluted plasma from obese ... -
Antarctic yeasts as a source of L-asparaginase: Characterization of a glutaminase-activity free L-asparaginase from psychrotolerant yeast Leucosporidium scottii L115
; ; ; ; ; ; ; ; ; Sette, Lara Durães et al. (Process Biochemistry, 2023) [Artigo]
Microorganisms from extreme environments, such as the Antarctic ecosystems, have a great potential to produce enzymes with novel characteristics. Within this context, L-asparaginase (ASNase) obtained from yeast species has ... -
Computational Strategies Targeting Inhibition of Helicobacter pylori and Cryptococcus neoformans Ureases
; Nascimento-Júnior, Nailton M.; ; (Current Pharmaceutical Design, 2023) [Resenha]
Helicobacter pylori and Cryptococcus ssp. are pathogenic ureolytic microorganisms that cause several disorders in the host organism and, in severe cases, lead to death. Both infections have the urease enzyme as a key ... -
Effects of Supplementation of Zinc, Manganese, or Copper and Different Phytase Levels in Serum and Bone Acid and Alkaline Phosphatases of Broiler Chicks
Santos, L. F.J.; Gonçalves, Adriano Marques ; Neira, L. M. ; ; Macari, M. ; Laurentiz, A. C. ; Pizauro, J. M. (Revista Brasileira de Ciencia Avicola, 2023) [Artigo]
The knowledge of biological trace minerals and phytase requirements for modern broiler genotypes is not established and the pressure to reduce their usage in animal feeding due to environmental issues is increasing. Here, ... -
Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens
; ; ; ; ; ; ; Araújo, Ângela R.; Nunes, Emanuel V. dos S. ; et al. (Natural Product Research, 2023) [Artigo]
Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, ... -
Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model
Rosa, Ivana F.; ; ; ; ; Doretto, Lucas B. ; Souza, Beatriz M. ; Nakajima, Rafael T. ; ; et al. (International Journal of Molecular Sciences, 2023) [Artigo]
Although the exact mechanism of the pathogenesis of coronavirus SARS-CoV-2 (COVID-19) is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role ... -
Maternal dietary zinc status alters offspring female mammary gland development and response to acute 7,12-dimethylbenzanthracene insult
; Zapaterini, Joyce R.; Grassi, Tony F. ; Bidinotto, Lucas T. ; Fernandes, Ana Angélica H. ; Barbisan, Luis F. (Biotechnic and Histochemistry, 2023) [Artigo]
We evaluated the effects of prenatal and postnatal dietary zinc (Zn) deficiency or supplementation on mammary gland morphology and on acute response to 7,12-dimethylbenzanthracene (DMBA) in pubertal female rats. On gestational ... -
Bioprocess development for levulinic acid production using sugarcane biomass
dos Santos, Miquéias Gomes; Fogarin, Henrique Maziero ; Virginio da Silva, Débora Danielle ; Dussán, Kelly Johana (Sustainable Chemistry and Pharmacy, 2023) [Artigo]
Developing technologies for converting lignocellulosic biomass to products such as energy, fuels, and value-added chemicals is an important step in making biorefineries a feasible alternative to the current oil-based ... -
A new complex of silver(I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum β-lactamases (ESBL) inhibition activities
; ; ; ; ; ; Lustri, Bruna Cardinali; Moreira, Cristiano Gallina ; Ribeiro, Camila M. ; Pavan, Fernando R. et al. (Journal of Inorganic Biochemistry, 2023) [Artigo]
This article describes the in vitro antibacterial and β-lactamase inhibition of a novel silver(I) complex with the sulfonamide probenecid (Ag-PROB). The formula Ag2C26H36N2O8S2·2H2O for the Ag-PROB complex was proposed ... -
Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material
Fracasso, Julia Amanda Rodrigues; Ibe, Mariana Bittencourt ; da Costa, Luísa Taynara Silvério ; ; ; Brito, Gustavo Reis de ; Parron, Mariana Conti ; Pereira, Anderson Espírito do Santo ; Pegorin Brasil, Giovana Sant’Ana ; Farias Ximenes, Valdecir et al. (Gels, 2023) [Artigo]
Caryocar brasiliense Cambess is a plant species typical of the Cerrado, a Brazilian biome. The fruit of this species is popularly known as pequi, and its oil is used in traditional medicine. However, an important factor ... -
Profile of Bioactive Compounds in Orange Juice Related to the Combination of Different Scion/Rootstocks, Packaging and Storage
Martins, Rafaelly Calsavara; Leonel, Sarita ; ; Lima, Giuseppina Pace Pereira ; Leonel, Magali ; Putti, Fernando Ferrari ; Monteiro, Gean Charles ; Züge, Patrícia Graosque Ülguim ; Napoleão, Gabriel Maluf ; Figueira, Ricardo et al. (Horticulturae, 2023) [Artigo]
Citrus scion/rootstock combinations alter the concentration of bioactive compounds in orange juice. The shelf life of freshly squeezed juice can be maximized through packaging and storage. The profiles of ascorbic (AA), ... -
Effects of Resistance Exercise on Slow-Twitch Soleus Muscle of Infarcted Rats
Souza, Lidiane Moreira; ; ; Pagan, Luana Urbano ; Gatto, Mariana ; Damatto, Felipe Cesar ; Rodrigues, Eder Anderson ; Pontes, Thierres Hernani Dias ; Borim, Patricia Aparecida ; Fernandes, Ana Angelica Henrique et al. (Antioxidants, 2023) [Artigo]
Although current guidelines recommend resistance exercise in combination with aerobic training to increase muscle strength and prevent skeletal muscle loss during cardiac remodeling, its effects are not clear. In this ... -
Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PLpro Protein
Bitencourt, Natália Vitória; ; ; ; ; ; Santos-Filho, Norival Alves ; Cilli, Eduardo Maffud (Pharmaceutics, 2023) [Artigo]
Recent studies have shown that the peptide [des-Cys11,Lys12,Lys13-(p-BthTX-I)2K] (p-Bth) is a p-BthTX-I analog that shows enhanced antimicrobial activity, stability and hemolytic activity, and is easy to obtain compared ... -
Old Meets New: Mass Spectrometry-Based Untargeted Metabolomics Reveals Unusual Larvicidal Nitropropanoyl Glycosides from the Leaves of Heteropterys umbellata
Mannochio-Russo, Helena; ; ; ; ; Bolzani, Vanderlan S. (Journal of Natural Products, 2023) [Artigo]
The Aedes aegypti (Diptera: Culicidae) mosquito is the vector of several arboviruses in tropical and subtropical areas of the globe, and synthetic pesticides remain the most widely used combat strategy. This study describes ... -
Enzymatic hydrolysis of Moringa oleifera Lam flour using bromelain and fig by-products as sources of protease
Bustamante, Lady Johana Arismendi; Maisa, Davanso ; ; de Paula, Ariela Veloso ; ; Bassan, Juliana Cristina (Food Chemistry Advances, 2022) [Artigo]
Moringa oleifera Lamarck flour (MOF) has been recognized as a source of vegetable proteins; however, around 70.1±0.98% of protein can be called “insoluble protein”, for its resistance to gastrointestinal digestion. For ... -
Plant Defense Elicitation by the Hydrophobin Cerato-Ulmin and Correlation with Its Structural Features
; ; ; ; Cilli, Eduardo Maffud; ; ; ; ; (International Journal of Molecular Sciences, 2023) [Artigo]
Cerato-ulmin (CU) is a 75-amino-acid-long protein that belongs to the hydrophobin family. It self-assembles at hydrophobic–hydrophilic interfaces, forming films that reverse the wettability properties of the bound surface: ...