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dc.contributor.authorNwidu, Lucky Legbosi
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.date.accessioned2014-05-20T14:17:34Z
dc.date.available2014-05-20T14:17:34Z
dc.date.issued2012-10-01
dc.identifierhttp://dx.doi.org/10.4314/tjpr.v11i5.15
dc.identifier.citationTropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 11, n. 5, p. 807-813, 2012.
dc.identifier.issn1596-5996
dc.identifier.urihttp://hdl.handle.net/11449/25259
dc.description.abstractPurpose: To evaluate the amino acid, antioxidant and ionic profiles of Carpolobia lutea leaf (Polygalaceae) extract (CLL).Methods: The powdered leaf was macerated and subjected to gradient solvent extraction with n-hexane, chloroform, ethyl acetate and ethanol for 72 h to obtain their respective fractions. Amino acid analysis was by cation-exchange chromatography using automated amino acid analyser. Antioxidant potential was obtained by spectrophotometric assay using 2, 2-Diphenyl-1-picrylhydrazyl DPPH while elemental and ionic analyses were carried out by atomic absorption spectrophotometry and potentiometric titration, respectively.Results: Proline, alanine, serine, valine, glycine, glutamate and lysine were found in the ethanol fraction while lysine, phenyl alanine, glycine and serine were present in the ethyl acetate fraction but not in the non-polar fractions, n-hexane and chloroform. The ethyl acetate fraction contained more lysine, phenyl alanine, glycine and serine the other leaf fractions. Minimal radical scavenging activity of all the fractions was recorded. The most abundant cations in the extract were potassium and phosphorus (2.16 +/- 0.05 and 1.90 +/- 0.06 mg/g, respectively) while the most abundant anion was phosphate with a concentration of 23.23 +/- 4.61 mg/g for the aqueous leaf fractionConclusion: The study shows that CLL fractions contain variety of amino acids which could promote wound healing, as well as major and minor elemental ions which, as essential body electrolytes, are required for various metabolic processes in the body.en
dc.description.sponsorshipNiger Delta University Postgraduate Fellowship of Nigeria
dc.description.sponsorshipKhana LGA, Rivers State, Nigeria
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent807-813
dc.language.isoeng
dc.publisherPharmacotherapy Group
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.sourceWeb of Science
dc.subjectCarpolobia leafen
dc.subjectPolygalaceaeen
dc.subjectAmino aciden
dc.subjectAntioxidanten
dc.subjectIonic profileen
dc.titleAmino acid, Antioxidant and Ion Profiles of Carpolobia lutea Leaf (Polygalaceae)en
dc.typeArtigo
dcterms.licensehttp://www.ajol.info/index.php/tjpr/about/submissions#copyrightNotice
dcterms.rightsHolderPharmacotherapy Group
dc.contributor.institutionNiger Delta Univ
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationNiger Delta Univ, Fac Pharm, Dept Pharmacol & Toxicol, Wilberforce Isl, Bayelsa State, Nigeria
dc.description.affiliationSão Paulo State Univ UNESP, Dept Biochem, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Biochem, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, BR-14801970 Araraquara, SP, Brazil
dc.identifier.doi10.4314/tjpr.v11i5.15
dc.identifier.wosWOS:000310051800015
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
dc.identifier.lattes9424346762460416
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.orcid0000-0003-3032-2556
unesp.author.lattes9424346762460416
unesp.author.orcid0000-0002-4767-0904[2]
unesp.author.orcid0000-0003-3032-2556[3]
dc.relation.ispartofjcr0.444
dc.relation.ispartofsjr0,256
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