X-ray diffraction data of tibolone Delta(4) isomer (isotibolone)

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Data

2009-12-01

Autores

Antonio, Selma Gutierrez [UNESP]
Ferreira, Fabio Furlan
Barros Araujo, Gabriel Lima
Matos, Jivaldo do Rosario
Paiva-Santos, Carlos de Oliveira [UNESP]

Título da Revista

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Editor

J C P D S-int Centre Diffraction Data

Resumo

Tibolone is used for hormone reposition of postmenopause women and isotibolone is considered the major degradation product of tibolone. Isotibolone can also be present in tibolone API raw materials due to some inadequate synthesis. Its presence is then necessary to be identified and quantified in the quality control of both API and drug products. In this work we present the indexing of an isotibolone X-ray diffraction pattern measured with synchrotron light (lambda=1.2407 angstrom) in the transmission mode. The characterization of the isotibolone sample by IR spectroscopy, elemental analysis, and thermal analysis are also presented. The isotibolone crystallographic data are a=6.8066 angstrom, b=20.7350 angstrom, c=6.4489 angstrom, beta=76.428 degrees, V=884.75 angstrom(3), and space group P2(1), rho(o)= 1.187 g cm(-3), Z=2. (C) 2009 International Centre for Diffraction Data. [DOI: 10.1154/1.3257612]

Descrição

Palavras-chave

isotibolone, hormone, indexing, X-ray powder diffraction, synchrotron radiation

Como citar

Powder Diffraction. Newtown Sq: J C P D S-int Centre Diffraction Data, v. 24, n. 4, p. 337-342, 2009.