X-ray diffraction data of tibolone Delta(4) isomer (isotibolone)
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Data
2009-12-01
Autores
Antonio, Selma Gutierrez [UNESP]
Ferreira, Fabio Furlan
Barros Araujo, Gabriel Lima
Matos, Jivaldo do Rosario
Paiva-Santos, Carlos de Oliveira [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
J C P D S-int Centre Diffraction Data
Resumo
Tibolone is used for hormone reposition of postmenopause women and isotibolone is considered the major degradation product of tibolone. Isotibolone can also be present in tibolone API raw materials due to some inadequate synthesis. Its presence is then necessary to be identified and quantified in the quality control of both API and drug products. In this work we present the indexing of an isotibolone X-ray diffraction pattern measured with synchrotron light (lambda=1.2407 angstrom) in the transmission mode. The characterization of the isotibolone sample by IR spectroscopy, elemental analysis, and thermal analysis are also presented. The isotibolone crystallographic data are a=6.8066 angstrom, b=20.7350 angstrom, c=6.4489 angstrom, beta=76.428 degrees, V=884.75 angstrom(3), and space group P2(1), rho(o)= 1.187 g cm(-3), Z=2. (C) 2009 International Centre for Diffraction Data. [DOI: 10.1154/1.3257612]
Descrição
Palavras-chave
isotibolone, hormone, indexing, X-ray powder diffraction, synchrotron radiation
Como citar
Powder Diffraction. Newtown Sq: J C P D S-int Centre Diffraction Data, v. 24, n. 4, p. 337-342, 2009.