Electrochemical reduction and cathodic stripping voltammetric determination of clotrimazole
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Data
2001-04-01
Autores
Pereira, Francisco C. [UNESP]
Stradiotto, Nelson Ramos [UNESP]
Zanoni, Maria Valnice Boldrin [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Clotrimazol é reduzido em eletrodo de mercúrio em tampão fosfato pH > 6 através de um processo reversível de um elétron. O processo eletródico apresenta forte efeito de adsorção, o qual pode ser minimizado na presença de Triton X-100. Clotrimazol pode ser determinado em níveis de 50 ng mL-1 quando pré-acumulado durante 3 min à -0,20 V. O método proposto foi aplicado para determinação do fármaco em formulação comercial.
The reduction of clotrimazole at a mercury electrode, in phosphate buffer, pH>6, involves a reversible one-electron process. The electrochemical process presents a large contribution from adsorption effects. For the differential pulse polarographic determination the addition of Triton X-100 is recommended. Clotrimazole can be determined by cathodic stripping voltammetry at 50 ng mL-1 level when pre-accumulated for 3 min at an accumulation potential of -0.20 V. The proposed method is applied successfully for the determination of clotrimazole in a commercial formulation.
The reduction of clotrimazole at a mercury electrode, in phosphate buffer, pH>6, involves a reversible one-electron process. The electrochemical process presents a large contribution from adsorption effects. For the differential pulse polarographic determination the addition of Triton X-100 is recommended. Clotrimazole can be determined by cathodic stripping voltammetry at 50 ng mL-1 level when pre-accumulated for 3 min at an accumulation potential of -0.20 V. The proposed method is applied successfully for the determination of clotrimazole in a commercial formulation.
Descrição
Palavras-chave
clotrimazole, cyclic voltammetry, differential pulse polarography, cathodic stripping voltammetry
Como citar
Journal of the Brazilian Chemical Society. Sociedade Brasileira de Química, v. 12, n. 2, p. 202-207, 2001.