Show simple item record

dc.contributor.authorPrieto, A. M. [UNESP]
dc.contributor.authorSantos, A. G. [UNESP]
dc.contributor.authorCsipak, A. R. [UNESP]
dc.contributor.authorCaliri, C. M. [UNESP]
dc.contributor.authorSilva, I. C. [UNESP]
dc.contributor.authorArbex, M. A.
dc.contributor.authorSilva, F. S. [UNESP]
dc.contributor.authorMarchi, Mary Rosa Rodrigues de [UNESP]
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorSoares, C. P. [UNESP]
dc.date.accessioned2014-05-20T14:19:00Z
dc.date.available2014-05-20T14:19:00Z
dc.date.issued2012-12-15
dc.identifierhttp://dx.doi.org/10.1016/j.taap.2012.09.005
dc.identifier.citationToxicology and Applied Pharmacology. San Diego: Academic Press Inc. Elsevier B.V., v. 265, n. 3, p. 368-372, 2012.
dc.identifier.issn0041-008X
dc.identifier.urihttp://hdl.handle.net/11449/25721
dc.description.abstractEthanolic extract of Casearia sylvestris is thought to be antimutagenic. In this study, we attempted to determine whether this extract and casearin X (a clerodane diterpene from C. sylvestris) are protective against the harmful effects of airborne pollutants from sugarcane burning. To that end, we used the Tradescantia micronucleus test in meiotic pollen cells of Tradescantia pallida, the micronucleus test in mouse bone marrow cells, and the comet assay in mouse blood cells. The mutagenic compound was total suspended particulate (TSP) from air. For the Tradescantia micronucleus test, T. pallida cuttings were treated with the extract at 0.13, 0.25, or 0.50 mg/ml. Subsequently, TSP was added at 0.3 mg/ml, and tetrads from the inflorescences were examined for micronuclei. For the micronucleus test in mouse bone marrow cells and the comet assay in mouse blood cells, Balb/c mice were treated for 15 days with the extract-3.9, 7.5, or 15.0 mg/kg body weight (BW)-or with casearin X-03, 0.25, or 12 mg/kg BW after which they received TSP (3.75 mg/kg BW). In T. pallida and mouse bone marrow cells, the extract was antimutagenic at all concentrations tested. In mouse blood cells, the extract was antigenotoxic at all concentrations, whereas casearin X was not antimutagenic but was antigenotoxic at all concentrations. We conclude that C. sylvestris ethanolic extract and casearin X protect DNA from damage induced by airborne pollutants from sugarcane burning. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBIOprospecTA Program
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent368-372
dc.language.isoeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relation.ispartofToxicology and Applied Pharmacology
dc.sourceWeb of Science
dc.subjectTotal suspended particulateen
dc.subjectSugarcane burningen
dc.subjectChemopreventionen
dc.subjectDNA damageen
dc.subjectCasearia sylvestrisen
dc.titleChemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazilen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Elsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUNESP Univ Estadual Paulista, Coll Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil
dc.description.affiliationUNIFESP Fed Univ São Paulo, Paulista Coll Med, Dept Internal Med, São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Chem, Dept Analyt Chem, Araraquara, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Chem, Dept Organ Chem, Araraquara, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Coll Pharmaceut Sci, Dept Nat Principles & Toxicol, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Coll Pharmaceut Sci, Dept Clin Anal, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Chem, Dept Analyt Chem, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Chem, Dept Organ Chem, Araraquara, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Coll Pharmaceut Sci, Dept Nat Principles & Toxicol, Araraquara, Brazil
dc.identifier.doi10.1016/j.taap.2012.09.005
dc.identifier.wosWOS:000312610500011
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 05/58472-9
dc.description.sponsorshipIdFAPESP: 06/50892-1
dc.description.sponsorshipIdFAPESP: 03/02176-7
dc.description.sponsorshipIdBIOprospecTA Program: 2004/07932-7
dc.description.sponsorshipIdCNPq: 305615/2006-8
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes2543372149131902
dc.identifier.lattes2518006820764120
dc.identifier.lattes4702004904231248
dc.identifier.lattes4484083685251673
dc.identifier.orcid0000-0002-1516-7765
unesp.author.lattes2543372149131902
unesp.author.lattes2518006820764120[9]
unesp.author.lattes4702004904231248[10]
unesp.author.lattes4484083685251673
unesp.author.orcid0000-0002-1516-7765[10]
unesp.author.orcid0000-0001-8214-9957[9]
dc.relation.ispartofjcr3.616
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record