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dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorValli, Marilia [UNESP]
dc.contributor.authorPivatto, Marcos [UNESP]
dc.contributor.authorViegas, Claudio
dc.date.accessioned2014-05-20T14:20:13Z
dc.date.available2014-05-20T14:20:13Z
dc.date.issued2012-01-01
dc.identifierhttp://dx.doi.org/10.1351/PAC-CON-12-01-11
dc.identifier.citationPure and Applied Chemistry. Res Triangle Pk: Int Union Pure Applied Chemistry, v. 84, n. 9, p. 1837-1846, 2012.
dc.identifier.issn0033-4545
dc.identifier.urihttp://hdl.handle.net/11449/26071
dc.description.abstractNatural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1837-1846
dc.language.isoeng
dc.publisherInt Union Pure Applied Chemistry
dc.relation.ispartofPure and Applied Chemistry
dc.sourceWeb of Science
dc.subjectBrazilian biomesen
dc.subjectdrug discoveryen
dc.subjectmedicinal chemistryen
dc.subjectnatural productsen
dc.subjecttropical biodiversityen
dc.titleNatural products from Brazilian biodiversity as a source of new models for medicinal chemistryen
dc.typeArtigo
dcterms.licensehttp://www.iupac.org/publications/pac/publication_policy.html
dcterms.rightsHolderInt Union Pure Applied Chemistry
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.description.affiliationUniv Estadual Paulista, Dept Quim Inorgan, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Inst Quim,UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Alfenas, Inst Quim, LFQM, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Quim Inorgan, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Inst Quim,UNESP, BR-14801970 Araraquara, SP, Brazil
dc.identifier.doi10.1351/PAC-CON-12-01-11
dc.identifier.wosWOS:000307817300002
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 03/02176-7
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
dc.identifier.lattes4484083685251673
unesp.author.lattes4484083685251673
dc.relation.ispartofjcr5.294
dc.relation.ispartofsjr1,212
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