HPLC-ESIMSn Profiling, Isolation, Structural Elucidation, and Evaluation of the Antioxidant Potential of Phenolics from Paepalanthus geniculatus
Nenhuma Miniatura disponível
Data
2012-04-01
Autores
do Amaral, Fabiano Pereira [UNESP]
Napolitano, Assunta
Masullo, Milena
Santos, Lourdes Campaner dos [UNESP]
Festa, Michela
Vilegas, Wagner [UNESP]
Pizza, Cosimo
Piacente, Sonia
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Chemical Soc
Resumo
The methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC:ESIMSn was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).
Descrição
Palavras-chave
Como citar
Journal of Natural Products. Washington: Amer Chemical Soc, v. 75, n. 4, p. 547-556, 2012.