RSS 1.0Departamento de Química Orgânica
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Recent Submissions
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Bioenergy Recovery from Anaerobic Co-Digestion of Crude Glycerol and Domestic Sewage In-Series Reactor: Microbial Characterization and System Performance
Adames, Luan Vieira
; Jacobus, Ana Paula ; ; ; Pires, Lorena Oliveira ; Maintinguer, Sandra Imaculada (Bioenergy Research, 2022) [Artigo]
Experiments in series horizontal anaerobic reactors with fixed bed (HARFB) were conducted to evaluate the co-digestion of crude glycerol (CG) from biodiesel production and domestic sewage (DS) concerning the start-up ... -
Combining natural deep eutectic solvent and microwave irradiation towards the eco-friendly and optimized extraction of bioactive phenolics from Eugenia uniflora L.
Souza, Otávio Aguiar; Ramalhão, Vitória Giovanna da Silva ; Trentin, Lucas de Melo ; Funari, Cristiano Soleo ; ; Bolzani, Vanderlan da Silva ; Rinaldo, Daniel (Sustainable Chemistry and Pharmacy, 2022) [Artigo]
To design a green chemistry future, the development of new protocols for standardization of phytomedicines should consider both traditional and environmental parameters. In the present study, we developed a new natural ... -
Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera
; ; ; ; ; ; ; Cavalheiro, Alberto J.; (Natural Product Research, 2021) [Artigo]
In this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities ... -
A simple spectrophotometric method for the determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T
Rufino, José L.; Fernandes, Flávio C.B. ; Ruy, Mayara S. ; Pezza, Helena R. ; Pezza, Leonardo (Ecletica Quimica, 2010) [Artigo]
A simple, rapid, accurate and inexpensive spectrophotometric method for the determination of tetracycline and doxycycline has been developed. The method is based on the reaction between these drugs and chloramine-T in ... -
Multi-element determination of calcium, potassium and magnesium in medicinal plant by high-resolution continuum source atomic absorption spectrometry
Silva, Tiago Varão; Rêgo, Jardes Figuerêdo ; De Moraes, Mercedes ; Cavalheiro, Alberto José ; Gomes Neto, José Anchieta ; (Ecletica Quimica, 2012) [Artigo]
A simple and rugged method to determine Ca, K and Mg in a single aliquot of medicinal plants by high-resolution continuum source flame atomic absorption spectrometry is proposed. Secondary lines for Ca (239.856 nm) and K ... -
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design
; Pezza, Leonardo; Pezza, Helena R. ; Tognolli, João O. (Latin American Journal of Pharmacy, 2011) [Artigo]
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the ... -
Spectrophotometric determination of paracetamol in pharmaceuticals using microwave-assisted hydrolysis and a micellar medium
Sequinel, Rodrigo; Rufino, José L. ; Pezza, Helena R. ; Pezza, Leonardo (Latin American Journal of Pharmacy, 2011) [Artigo]
A new spectrophotometric method employing a micellar medium is proposed for the determination of paracetamol in pharmaceuticals. The method is based on the acid hydrolysis of paracetamol to p-aminophenol (PAP), which under ... -
Plant diversity from Brazilian Cerrado and Atlantic Forest as a tool for prospecting potential therapeutic drugs
Silva, Dulce Helena Siqueira; Castro-Gamboa, Ian ; Bolzani, Vanderlan Da Silva (Comprehensive Natural Products II: Chemistry and Biology, 2010) [Capítulo de livro]
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Composition and screening of antifungal activity against Cladosporium sphaerospermum and Cladosporium cladosporioides of essential oils of leaves and fruits of Piper species
Morandim, Andreia de A.; ; ; Alecio, Alberto C. ; ; ; de Oliveira, José E. ; Furlan, Maysa (African Journal of Biotechnology, 2010) [Artigo]
This study investigated the composition and antifungal activity against Cladosporium sphaerospermum and Cladosporium cladosporioides of essential oils of leaves of Piper cernuum, Piper diospyrifolium, Piper crassinervium, ... -
Determinação espectrofotométrica de hexametilenotetramina (HMT) em medicamentos, utilizando ácido cromotrópico e forno de micro-ondas
; Pezza, Leonardo; Pezza, Helena Redigolo (Quimica Nova, 2009) [Artigo]
This paper proposes a methodology for spectrophotometric determination of hexamethylenetetramine (HMT) by using chromotropic acid in a phosphoric acid media employing a domestic microwave oven as a source of heating. The ... -
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
Ricardo, Maria A. G.; Andreo, Márcio A. ; Cavalheiro, Alberto J. ; Gamboa, Ian C. ; Bolzani, Vanderlan S. ; Silva, Dulce H. S. (Arkivoc, 2004) [Artigo]
The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging ... -
Isolation, optimization of production and structure-activity relationship studies of monocillin I, the cytotoxic constituent of Paraphaeosphaeria quadriseptata
; Carbonezi, Carlos A.; ; ; ; ; ; ; ; Bolzani, Vanderlan da S. et al. (Journal of Antibiotics, 2004) [Artigo]
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Potentiometric determination of alendronate in pharmaceutical formulations
De Haro Moreno, Andréia; Pezza, Helena Redigolo ; Pezza, Leonardo (Chemia Analityczna, 2004) [Artigo]
A simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically ... -
Lignoids in seedlings of Virola sebifera
; Cavalheiro, Alberto José; (Phytochemical Analysis, 2000) [Artigo]
Quantitative analysis carried out by high performance liquid chromatography indicated the accumulation of a major secondary compound in seedlings of Virola sebifera which was isolated and identified as the lignan ... -
Quantitative determination of maitenin and 22β-hydroxymaitenin in callus of Maytenus aquifolium (Celastraceae) by reverse phase high performance liquid chromatography
Corsino, Joaquim; Alécio, Alberto Camilo ; Ribeiro, Maria Lücia ; Furlan, Maysa ; ; ; (Phytochemical Analysis, 1998) [Artigo]
Explants of Maytenus aquifolium were induced to form callus and, subsequently, suspension cultures. The isolation of natural products from callus led to the identification of the cytotoxic triterpene quinonemethides, ... -
Antifungal iridoids from the stems of Tocoyena formosa
Bolzani, Vanderlan Da Silva; Trevisan, Ligia Maria Vetoratto ; ; (Journal of the Brazilian Chemical Society, 1996) [Artigo]
A new antifungal iridoid compound, together with three active known iridoids, galioside, galioside aglucone, and apodanthoside, as well as 3-O-β-D-glucopyranosyl-28-O-β-D-glucopyranosyl quinovic acid and quercetin-3-O-me ... -
Planejamento racional de fármacos baseado em produtos naturais
; Bolzani, Vanderlan Da S. (Quimica Nova, 2001) [Artigo]
In the area of drug discovery, natural products represent a myriad of templates for new lead discovery. It is, however, most unlikely that the bioactive principle itself shall become a drug; it is much more likely that a ... -
Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes
(Planta Medica, 2019) [Artigo]Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in ... -
Comparative Transcriptome Profiling of Maytenus ilicifolia Root and Leaf
Santoni, Mariana Marchi; de Lima, João Vítor Félix ; ; de Souza Moreira, Tatiana Maria ; Valentini, Sandro Roberto ; Furlan, Maysa ; (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2021) [Trabalho apresentado em evento]
Plants produce a wide variety of compounds called secondary metabolites (SMs), which are extremely important for their survival. SMs have also medicinal applications, but as chemical synthesis is not economically viable, ... -
Molecular networks: An analysis on annotations and discovery of new assets
Pilon, Alan C.; Vieira, Natália C. ; ; ; ; ; Castro-Gamboa, Ian ; (Quimica Nova, 2021) [Artigo]
To speed up the discovery of bioactive natural products (NP), chemists have sought advanced approaches in analytical and computational chemistry in attempt to organize and extract information from large data sets. In this ...