RSS 1.0Departamento de Química Orgânica
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NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii
; ; ; ; ; ; ; ; Bolzani, Vanderlan Da Silva
; et al. (Journal of Natural Products, 2018) [Artigo]
The ethyl acetate extract of the aerial parts of Chresta martii showed significant in vitro NF-κB inhibition. Bioactivity-guided isolation was undertaken using HPLC microfractionation to localize the active compounds. ... -
Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Vieira, Gabriela Alves Licursi; ; Regasini, Luis Octávio ; Cotinguiba, Fernando ; ; ; Furlan, Maysa ; Cicarelli, Regina Maria Barretto (Brazilian Journal of Infectious Diseases, 2018) [Artigo]
The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas’ disease. This is a serious parasitic disease that occurs in Latin ... -
A paper platform for colorimetric determination of aluminum hydrochloride in antiperspirant samples
Silvestre, Amanda Letícia Polli; Milani, Maria Izabel ; Rossini, Eduardo Luiz ; Pezza, Leonardo ; Pezza, Helena Redigolo (Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2018) [Artigo]
A simple, fast, low-cost, portable, and eco-friendly method using a spot test on a paper platform, together with diffuse reflectance spectroscopy, was developed and validated for the quantification of aluminum hydrochloride, ... -
Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities
Chapla, Vanessa M.; Zeraik, Maria L. ; Cafeu, Mariana C. ; ; Cavalheiro, Alberto J. ; Bolzani, Vanderlan S. ; ; ; Araujo, Angela R. (Journal of the Brazilian Chemical Society, 2018) [Artigo]
One new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known ... -
Crude leaf extracts of piperaceae species downmodulate inflammatory responses by human monocytes
Finato, Angela Carolina; Fraga-Silva, Thais Fernanda ; Uliana Carvalho Prati, Amanda ; Alves de Souza, Amauri ; Mazzeu, Bruna Fonseca ; Felippe, Lidiane Gaspareto ; Pinto, Rute Alves ; De Assis Golim, Marjorie ; Sueli Parreira Arruda, Maria ; Furlan, Maysa et al. (PLoS ONE, 2018) [Artigo]
In this study, we aimed to evaluate the immunomodulatory effects of crude leaf extracts from Piper gaudichaudianum Kunth, P. arboreum Aub., P. umbellata L., P. fuligineum Kunth, and Peperomia obtusifolia A. Dietr. on an ... -
A Cyclotide Isolated from Noisettia orchidiflora (Violaceae)
Bobey, Antonio Fernández; Pinto, Meri Emili Ferreira ; Cilli, Eduardo Maffud ; ; Bolzani, Vanderlan Da Silva (Planta Medica, 2018) [Artigo]
Biologically active cyclotides have been found on some flowering plants species and are involved in the role of the plant protection. As part of studies focusing on peptides from Brazilian plant species, we are reporting ... -
A simple electrochemical method to monitor an azo dye reaction with a liver protein
Materón, Elsa Maria; Marchetto, Reinaldo ; Araujo, Angela Regina ; Vega-Chacon, Jaime ; ; Jafelicci, Miguel ; ; ; Zanoni, Maria Valnice Boldrin (Analytical Biochemistry, 2018) [Artigo]
Disperse Orange 37 (DO37) is an efficient azo dye for dyeing synthetic textile materials owing to its resistance to degradation that may also be harmful to humans as DO37 is not entirely eliminated in wastewater treatment. ... -
Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria
Pinto, Meri Emili F.; ; ; Bobey, Antonio F. ; ; ; ; ; ; et al. (Journal of Natural Products, 2018) [Artigo]
Two new bracelet cyclotides from roots of Pombalia calceolaria with potential anticancer activity have been characterized in this work. The cyclotides Poca A and B (1 and 2) and the previously known CyO4 (3) were de novo ... -
Kavalactones and benzoic acid derivatives from leaves of piper fuligineum kunth (Piperaceae)
Mazzeu, Bruna F.; Felippe, Lidiane G. ; ; ; Furlan, Maysa (Journal of the Brazilian Chemical Society, 2018) [Artigo]
The known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methox ... -
Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents
; Fraige, Karina; Leme, Gabriel Mazzi ; da Silva Bolzani, Vanderlan ; ; Cavalheiro, Alberto J. ; ; Funari, Cristiano Soleo (Analytical and Bioanalytical Chemistry, 2018) [Artigo]
Over the past six decades, acetonitrile (ACN) has been the most employed organic modifier in reversed-phase high-performance liquid chromatography (RP-HPLC), followed by methanol (MeOH). However, from the growing environmental ... -
Desenvolvimento de método espectrofotométrico ambientalmente mais limpo para análise de nitrito em salsichas
Martins, Ângela Pinheiro; Luiz, Vitor Hugo Marques ; Pezza, Leonardo ; Pezza, Helena Redigolo (Ecletica Quimica, 2015) [Artigo]
A clean environmental spectrophotometric method for the analysis of nitrite using a new diazotizing reagent is reported. The proposed method is based on diazotization-coupling reaction between dapsone, nitrite and ... -
Friedelin in maytenus ilicifolia is produced by friedelin synthase isoforms
Alves, Thaís B.; Souza-Moreira, Tatiana M. ; Valentini, Sandro R. ; Zanelli, Cleslei F. ; Furlan, Maysa (Molecules, 2018) [Artigo]
Triterpenes are interesting compounds because they play an important role in cell homeostasis and a wide variety exhibiting defense functions is produced by plant secondary metabolism. Those same plant secondary metabolites ... -
Bioconversion of crude glycerol from waste cooking oils into hydrogen by sub-tropical mixed and pure cultures
Rodrigues, Caroline Varella; Nespeca, Maurílio Gustavo ; ; de Oliveira, José Eduardo ; ; Maintinguer, Sandra Imaculada (International Journal of Hydrogen Energy, 2018) [Artigo]
This study compared the biohydrogen generation by sub-tropical mixed and pure cultures from the crude glycerol from the biodiesel production using waste cooking oils (WCO). The crude glycerol was pretreated by pH adjustment. ... -
Biosynthetic insights into p-Hydroxybenzoic acid-Derived benzopyrans in piper gaudichaudianum
Batista, Andrea N. L.; ; Souza‑Moreira, Tatiana M. ; Valentini, Sandro R. ; ; Zanelli, Cleslei F. ; Furlan, Maysa (Journal of the Brazilian Chemical Society, 2018) [Artigo]
Piper gaudichaudianum Kunth (Piperaceae) accumulates gaudichaudianic acid, a prenylated benzopyran, as its major component. Interestingly, this trypanocidal compound occurs as a racemic mixture. Herein, transcriptomic ... -
Hydrogen bioproduction with anaerobic bacteria consortium from brewery wastewater
Pachiega, Renan; Rodrigues, Mayara Franco ; Rodrigues, Caroline Varella ; ; ; De Oliveira, José Eduardo ; Maintinguer, Sandra Imaculada (International Journal of Hydrogen Energy, 2018) [Artigo]
Biohydrogen production is a cheap and clean way to obtain hydrogen gas. In subtropical countries such as Brazil the average temperatures of 27 °C can favor the hydrogen producing bacteria growth. A mixed culture was obtained ... -
An overview of the main foodstuff sample preparation technologies for tetracycline residue determination
Pérez-Rodríguez, Michael; ; Pezza, Leonardo ; Pezza, Helena Redigolo (Talanta, 2018) [Resenha]
Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in ... -
Reliable discriminant analysis tool for controlling the roast degree of coffee samples through chemical markers approach
de Toledo, Paulo R. A. B.; ; Pezza, Helena R. ; Pezza, Leonardo ; ; (European Food Research and Technology, 2017) [Artigo]
Roasting is one of the most influencing stages of coffee processing. Accordingly, a discriminant analysis (DA) was carried out with the objective of identifying key compounds (chemical markers) that enable a differentiation ... -
Fingerprint and authenticity roasted coffees by 1H-NMR: the Brazilian coffee case
; de Moura Ribeiro, Marcos Vinícius; de Toledo, Paulo Roberto Aparecido Bueno ; Boralle, Nivaldo ; Pezza, Helena Redigolo ; Pezza, Leonardo (Food Science and Biotechnology, 2018) [Artigo]
With globalization, it has become necessary to adopt policies to regulate the coffee market, addressing problems including the authenticity and traceability of products. It is therefore important to establish methodologies ... -
Obtaining and Characterization of Mesophilic Bacterial Consortia from Tropical Sludges Applied on Biohydrogen Production
Pachiega, Renan; ; ; Hatanaka, Rafael Rodrigues ; de Oliveira, José Eduardo ; Maintinguer, Sandra Imaculada (Waste and Biomass Valorization, 2018) [Artigo]
The biohydrogen production from different tropical sludges of biologic treatment plants was investigated in anaerobic batch reactors fed with sucrose in concentrations similar to food wastewaters. The tropical sludges ... -
Biologically Active Orbitides from the Euphorbiaceae Family
Ramalho, Suelem D.; Pinto, Meri Emili F. ; ; Bolzani, Vanderlan S. (Planta Medica, 2018) [Resenha]
A comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, ...