RSS 1.0Departamento de Química Orgânica
Browse by
Recent Submissions
-
Bioprospecting as a strategy for conservation and sustainable use of the Brazilian Flora
Silva, Dulce Helena Siqueira
; Mannochio-Russo, Helena ; ; ; ; Bolzani, Vanderlan da Silva ; Vilegas, Wagner ; (Biota Neotropica, 2022) [Artigo]
In Brazil, research with natural products had a strong impulse when FAPESP supported the creation of the Laboratory of Chemistry of Natural Products of the Institute of Chemistry of USP (1966). In 1999, FAPESP launched the ... -
Design of volatile organic compounds profiles of roasted Coffea arabica extracts produced by supercritical and conventional solvents
de Toledo, Paulo R. A. B.; ; ; Pezza, Helena R. ; ; ; Pezza, Leonardo ; ; (International Journal of Food Science and Technology, 2022) [Artigo]
This work addresses the potential of supercritical fluid extraction (SFE) to design volatile organic compounds (VOCs) profiles using roasted Coffea arabica. On the whole, 57 VOCs were identified by HS-SPME/GC–MS. A full ... -
Levetiracetam analogs: chemoenzymatic synthesis, absolute configuration assignment and evaluation of cholinesterase inhibitory activities
de Freitas Milagre, Cintia Duarte; do Amaral, Bruno Sergio ; ; ; ; Milagre, Humberto Marcio Santos (Ecletica Quimica, 2022) [Artigo]
A chemoenz matic a roach for the synthesis of α-N-heterocyclic ethyl- and phenylacetamides, levetiracetam analogs, is described. Eight nitrile substrates were prepared through the N-alkylation of heterocycles (2-pyrrolidinone, ... -
Effect of Fe3O4 nanoparticles on microbial diversity and biogas production in anaerobic digestion of crude glycerol
Boscaro, Mateus Eugenio; Canaver Marin, Danieli Fernanda ; Camila da Silva, Daiana ; Maintinguer, Sandra Imaculada (Biomass and Bioenergy, 2022) [Artigo]
This study investigated the effects of citrate-coated Fe3O4 nanoparticles in the anaerobic digestion of crude glycerol, the main by-product of the biodiesel industry. Fe3O4 nanoparticles were synthesized by the coprecipitation ... -
Phenolic compounds and bioactive extract produced by endophytic fungus Coriolopsis rigida
; ; Araujo, Angela Regina; (Natural Product Research, 2022) [Artigo]
Coriolopsis rigida was isolated as an endophytic fungus from the medicinal plant Cochlospermum regium, and their production of secondary metabolites has not yet been investigated. Thus, the endophyte was cultivated on rice ... -
In vivo antifungal activity and biocompatibility of Cryptocarya moschata
de Oliveira Zoccolotti, Jacqueline; Cavalheiro, Alberto José ; Tasso, Camilla Olga ; de Oliveira, Caroline Correa ; Ribas, Beatriz Ribeiro ; Ferrisse, Túlio Morandin ; de Souza Costa, Carlos Alberto ; Jorge, Janaina Habib (Archives of Microbiology, 2022) [Artigo]
The objective of this study was evaluate, in vivo model, the antifungal activity of Cryptocarya moschata extract against Candida albicans and its biocompatibility. The animals (N = 50) were divided into groups (n = 5): ... -
Metabolic Profiling of Inga Species with Antitumor Activity
Lima, Nerilson M.; ; Marqui, Sara R. ; Falcoski, Thaís de O. R. S. ; Navegante, Geovana ; Soares, Christiane P. ; ; ; ; et al. (Molecules, 2022) [Artigo]
This work evaluated the metabolic profiling of Inga species with antitumor potential. In addition, we described the antigenotoxicity of polyphenols isolated from I. laurina and a proteomic approach using HepG2 cells after ... -
In vitro antiviral activity of piperidine alkaloids from Senna spectabilis flowers on Chikungunya virus infection
; ; ; Martins, Daniel Oliveira Silva; ; da Silva Bolzani, Vanderlan ; Jardim, Ana Carolina Gomes ; (Pharmacological Reports, 2022) [Artigo]
Background: Chikungunya fever is an endemic disease caused by the Chikungunya virus (CHIKV). To date there is no antiviral treatment against this infection or licensed vaccine to prevent it. Our study aims to evaluate ... -
Evaluation of Candida rugosa Lipase Immobilized on Magnetic Nanoparticles in Enzymatic/Chemical Hydroesterification for Biodiesel Production
Domingues, Otávio; Remonatto, Daniela ; dos Santos, Letícia Karen ; ; Flumignan, Danilo Luiz ; de Paula, Ariela Veloso (Applied Biochemistry and Biotechnology, 2022) [Artigo]
This study aimed to (i) prepare functionalized maghemite nanoparticles for immobilization of Candida rugosa lipase (CRL) by covalent binding, (ii) evaluate the application of the immobilized derivative in the hydrolysis ... -
Dados espectrométricos e espectroscópicos relativos ao projeto regular FAPESP 2019/15230-8
(2023) [Dado de pesquisa] -
Continuous Long-Term Anaerobic Co-digestion of Crude Glycerol and Domestic Sewage: Plug-Flow In-Series Reactor Performance and Microbiota Acclimatization
Adames, Luan Vieira; Pires, Lorena Oliveira ; Maintinguer, Sandra Imaculada (Bioenergy Research, 2022) [Artigo]
Long-term operation of four in-series horizontal anaerobic reactors with fixed bed (HARFB) R1, R2, R3, and R4 was conducted to evaluate the co-digestion of domestic sewage (DS) with different proportions of crude glycerol ... -
Scenarios of public policies adopted by the national biodiesel production program in Brazil
Maintinguer, Sandra Imaculada; ; ; (Revista Tecnologia E Sociedade, 2022) [Artigo]
Brazil is among the four largest biodiesel producers. Several challenges need to be overcome, since economic activities of this kind require regular production, technical skills and effective public policies that boost ... -
Metabolic profiling and cytotoxic activity of methanol extracts from Chamaecrista duckeana (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE)
; ; ; ; Cavalheiro, Alberto Jose; (Quimica Nova, 2022) [Artigo]
The genus Chamaecrista comprises more than 330 species, with only a few studies on their chemical composition and biologic activities. In this study, the phytochemical profile of leaf, stems, and fruits extracts of the C. ... -
Bioenergy Recovery from Anaerobic Co-Digestion of Crude Glycerol and Domestic Sewage In-Series Reactor: Microbial Characterization and System Performance
Adames, Luan Vieira; Jacobus, Ana Paula ; ; ; Pires, Lorena Oliveira ; Maintinguer, Sandra Imaculada (Bioenergy Research, 2022) [Artigo]
Experiments in series horizontal anaerobic reactors with fixed bed (HARFB) were conducted to evaluate the co-digestion of crude glycerol (CG) from biodiesel production and domestic sewage (DS) concerning the start-up ... -
Combining natural deep eutectic solvent and microwave irradiation towards the eco-friendly and optimized extraction of bioactive phenolics from Eugenia uniflora L.
Souza, Otávio Aguiar; Ramalhão, Vitória Giovanna da Silva ; Trentin, Lucas de Melo ; Funari, Cristiano Soleo ; ; Bolzani, Vanderlan da Silva ; Rinaldo, Daniel (Sustainable Chemistry and Pharmacy, 2022) [Artigo]
To design a green chemistry future, the development of new protocols for standardization of phytomedicines should consider both traditional and environmental parameters. In the present study, we developed a new natural ... -
Chemical composition, in vitro cytotoxic and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera
; ; ; ; ; ; ; Cavalheiro, Alberto J.; (Natural Product Research, 2021) [Artigo]
In this study, we investigated the phenolic and antioxidant content, cytotoxic, and anticholinesterase activities of flower extracts of Senna spectabilis var. excelsa and Senna macranthera. The antioxidant activities ... -
A simple spectrophotometric method for the determination of tetracycline and doxycycline in pharmaceutical formulations using chloramine-T
Rufino, José L.; Fernandes, Flávio C.B. ; Ruy, Mayara S. ; Pezza, Helena R. ; Pezza, Leonardo (Ecletica Quimica, 2010) [Artigo]
A simple, rapid, accurate and inexpensive spectrophotometric method for the determination of tetracycline and doxycycline has been developed. The method is based on the reaction between these drugs and chloramine-T in ... -
Multi-element determination of calcium, potassium and magnesium in medicinal plant by high-resolution continuum source atomic absorption spectrometry
Silva, Tiago Varão; Rêgo, Jardes Figuerêdo ; De Moraes, Mercedes ; Cavalheiro, Alberto José ; Gomes Neto, José Anchieta ; (Ecletica Quimica, 2012) [Artigo]
A simple and rugged method to determine Ca, K and Mg in a single aliquot of medicinal plants by high-resolution continuum source flame atomic absorption spectrometry is proposed. Secondary lines for Ca (239.856 nm) and K ... -
Spectrophotometric determination of captopril through charge transfer complex formation using fractional factorial and central composite design
; Pezza, Leonardo; Pezza, Helena R. ; Tognolli, João O. (Latin American Journal of Pharmacy, 2011) [Artigo]
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (π acceptor). The different experimental parameters that affect the ... -
Spectrophotometric determination of paracetamol in pharmaceuticals using microwave-assisted hydrolysis and a micellar medium
Sequinel, Rodrigo; Rufino, José L. ; Pezza, Helena R. ; Pezza, Leonardo (Latin American Journal of Pharmacy, 2011) [Artigo]
A new spectrophotometric method employing a micellar medium is proposed for the determination of paracetamol in pharmaceuticals. The method is based on the acid hydrolysis of paracetamol to p-aminophenol (PAP), which under ...