RSS 1.0Departamento de Química Orgânica
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Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots
Inácio, Marielle Cascaes
; Paz, Tiago Antunes ; ; Furlan, Maysa (Journal of Chemical Ecology, 2019) [Artigo]
Peritassa campestris (Celastraceae) root bark accumulates potent antitumor quinonemethide triterpenes (QMTs). When grown in their natural habitat, plants of the family Celastraceae produce different QMTs such as celastrol ... -
1H NMR spectroscopy combined with multivariate data analysis for differentiation of Brazilian lager beer according to brewery
da Silva, Luis Augusto; ; Pezza, Helena Redigolo ; Pezza, Leonardo (European Food Research and Technology, 2019) [Artigo]
In this study, 1H NMR spectroscopy was used to classify samples of beer, considering three categories (Ambev, Heineken, and Grupo Petrópolis), employing chemometric methods: principal component analysis (PCA), partial least ... -
Assessment of novel C-4 methylated tetraketide by HPLC-SPE-TT in saccharicola sp., an endophytic fungus in Eugenia Jambolana Lam
Borges, Maiara S.; Biasetto, Carolina R. ; ; ; Costa, Mayra F. ; Bolzani, Vanderlan S. ; Araujo, Angela R. (Journal of the Brazilian Chemical Society, 2019) [Artigo]
A new compound named methyl (6S,7S,2E,4E)-6,7-dihydroxy-4,6-dimethyl octanoate was isolated from Saccharicola sp. using high performance liquid chromatography-solid phase extraction-transfer tube (HPLC-SPE-TT), together ... -
Diketopiperazines and arylethylamides produced by Schizophyllum commune, an endophytic fungus in Alchornea glandulosa
Biasetto, Carolina Rabal; Somensi, Andressa ; ; ; ; ; Da Silva Bolzani, Vanderlan ; Araújo, Angela Regina (Ecletica Quimica, 2019) [Artigo]
Chemical investigation of the crude PDB extract obtained from the endophytic fungus Schizophyllum commune afforded the pure substances, cyclo(L-Pro-L-Val) (1), uracil (2), cyclo(Pro-Tyr) (3), p-hydroxybenzoic acid (4) and ... -
Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis
Funari, Cristiano Soleo; ; ; Fraige, Karina ; Cavalheiro, Alberto José ; da Silva Bolzani, Vanderlan ; ; (Food Research International, 2019) [Artigo]
Ethanolic extracts of propolis are consumed for their health benefits even though direct consumption of alcoholic extracts is not always ideal. Natural Deep Eutectic Solvents (NADES) can potentially extract similar compounds ... -
Combined use of tandem mass spectrometry and computational chemistry to study 2H-chromenes from Piper aduncum
Souza, Amauri Alves; ; Castro-Gamboa, Ian ; Furlan, Maysa (Journal of Mass Spectrometry, 2019) [Artigo]
Natural 2H-chromenes were isolated from the crude extract of Piper aduncum (Piperaceae) and analyzed by electrospray ionization tandem mass spectrometry (ESI-MS/MS) applying collision-induced dissociation. Density functional ... -
Antibacterial activity of prenylated benzopyrans from Peperomia obtusifolia (Piperaceae)
; ; ; ; ; Furlan, Maysa; ; ; (Natural Product Research, 2019) [Artigo]
Peperomia obtusifolia is a herbaceous perennial plant native to the Americas reported as a traditional medicine to treat snake bites and as a skin cleanser. The bioassay-guided fractionation of crude extracts from aerial ... -
Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
Politi, Flávio Augusto Sanches; Fantatto, Rafaela Regina ; da Silva, Alexander Alves ; Moro, Isabela Jacob ; ; Camargo-Mathias, Maria Izabel ; ; ; Furlan, Maysa (Experimental and Applied Acarology, 2019) [Artigo]
The cattle tick Rhipicephalus microplus is a great sanitary problem and causes huge losses to livestock, being a vector of important diseases. The aim of this work was to verify the action of plant-derived material obtained ... -
Ecological insights to track cytotoxic compounds among maytenus ilicifolia living individuals and clones of an ex situ collection
Pavarini, Daniel Petinatti; Selegato, Denise Medeiros ; Castro-Gamboa, Ian ; Do Sacramento, Luiz Vitor Silva ; Furlan, Maysa (Molecules, 2019) [Artigo]
Biodiversity is key for maintenance of life and source of richness. Nevertheless, concepts such as phenotype expression are also pivotal to understand how chemical diversity varies in a living organism. Sesquiterpene ... -
Paper platform for determination of bumetanide in human urine samples to detect doping in sports using digital image analysis
Luiz, Vitor Hugo Marques; Lima, Liliane Spazzapam ; Rossini, Eduardo Luiz ; Pezza, Leonardo ; Pezza, Helena Redigolo (Microchemical Journal, 2019) [Artigo]
Development and application of a new, simple, inexpensive, and eco-friendly method is presented for the quantification of bumetanide in human urine samples for the detection of doping in sports. The method involves the use ... -
Determination of amino acids in gym supplements using digital images and paper platform coupled to diffuse reflectance spectroscopy and USB device
Catelani, Tiago Augusto; Bittar, Dayana Borges ; Pezza, Leonardo ; Pezza, Helena Redigolo (Talanta, 2019) [Artigo]
New and reliable methodologies are described for the determination of amino acids in gym supplements, offering rapid and clean analysis, with low generation of waste. The proposed methods are based on the reaction between ... -
Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves
Fraige, Karina; ; ; Funari, Cristiano Soleo ; Cavalheiro, Alberto José ; ; Bolzani, Vanderlan da Silva (Journal of Separation Science, 2019) [Artigo]
Natural deep eutectic solvents have been used as an alternative to organic solvents for the extraction of plants metabolites, allowing for the extraction of compounds of different polarities, while being inexpensive, ... -
Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species
Ramalho, Suelem D.; ; ; ; ; Bolzani, Vanderlan S. ; (Journal of Natural Products, 2018) [Artigo]
Orbitides are small cyclic peptides with a diverse range of therapeutic bioactivities. They are produced by many plant species, including those of the Jatropha genus. Here, the objective was to provide new structural ... -
Discrimination of Brazilian lager beer by 1H NMR spectroscopy combined with chemometrics
da Silva, Luis Augusto; ; ; Pezza, Helena Redigolo ; Pezza, Leonardo (Food Chemistry, 2019) [Artigo]
1H NMR spectroscopy combined with chemometrics was employed to discriminate lager beer samples from two different classes, according to their style and information provided on the label. Partial replacement of barley malt ... -
Mass spectral similarity networking and gas-phase fragmentation reactions in the structural analysis of flavonoid glycoconjugates
Pilon, Alan Cesar; ; ; Bolzani, Vanderlan Da Silva ; ; Castro-Gamboa, Ian ; Carnevale Neto, Fausto (Analytical Chemistry, 2019) [Artigo]
Flavonoids represent an important class of natural products with a central role in plant physiology and human health. Their accurate annotation using untargeted mass spectrometry analysis still relies on differentiating ... -
Plant Metabolomics Using NMR Spectroscopy
Selegato, Denise Medeiros; ; (Methods in Molecular Biology, 2019) [Capítulo de livro]
The major goal in plant metabolomics is to study complex extracts for the purposes of metabolic exploration and natural products discovery. To achieve this goal, plant metabolomics relies on accurate and selective acquisition ... -
Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
Medina, Rebeca P.; Araujo, Angela R. ; ; ; ; ; ; ; ; Silva, Dulce H. S. (Scientific Reports, 2019) [Artigo]
A chemical study of the EtOAc extract of Nemania bipapillata (AT-05), an endophytic fungus isolated from the marine red alga Asparagopsis taxiformis - Falkenbergia stage, led to the isolation of five new botryane sesquiterpenes, ... -
Natural Products: Perspectives and Challenges for use of Brazilian Plant Species in the Bioeconomy
Valli, Marilia; Bolzani, Vanderlan S. (Anais da Academia Brasileira de Ciencias, 2019) [Artigo]
The development of our society has been based on the use of biodiversity, especially for nutrition, medicines and beauty. Brazil is the nation with the largest biodiversity in the world, with a rich chemical diversity, ... -
A new acridone with antifungal properties against Candida spp. and dermatophytes, and antibiofilm activity against C. albicans
; ; ; ; Marques, B. C.; dos Santos, M. B. ; ; Bolzani, V. S. ; ; Regasini, L. O. et al. (Journal of Applied Microbiology, 2019) [Artigo]
Aim: The increase in the number of fungal infections worldwide, coupled with the limitations of current antifungal chemotherapy, demand the development of safe and effective new antifungals. Here, we presented the synthesis ... -
Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates
Pilon, Alan Cesar; ; ; Bolzani, Vanderlan Da Silva ; ; Castro-Gamboa, Ian ; Carnevale Neto, Fausto (Analytical Chemistry, 2018) [Artigo]
Flavonoids represent an important class of natural products with a central role in plant physiology and human health. Their accurate annotation using untargeted mass spectrometry analysis still relies on differentiating ...