Now showing items 1-4 of 4
4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase
(Current Medicinal Chemistry, 2012-11-01) [Resenha]
The excessive activation of neutrophils generates reactive oxygen species (ROS) and the secretion of primary granular enzymes, such as myeloperoxidase (MPO), which is implicated in numerous inflammatory diseases. The aim ...
Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization
(Current Medicinal Chemistry, 2012-09-01) [Resenha]
The therapeutic potential of gallic acid and its derivatives as anti-cancer, antimicrobial and antiviral agents is well known. We have examined the mechanism by which natural gallic acid and newly synthesized gallic acid ...
Protocatechuic Acid Alkyl Esters: Hydrophobicity As a Determinant Factor for Inhibition of NADPH Oxidase
(Current Medicinal Chemistry, 2012-10-01) [Resenha]
This study presents the increased efficiency of NADPH oxidase inhibition produced by esterification of protocatechuic acid (P0). Alkyl esters bearing chain lengths of 4 (P4), 7 (P7) and 10 (P10) carbons were synthesized ...
The genus psychotria: Phytochemistry, chemotaxonomy, ethnopharmacology and biological properties
(Journal of the Brazilian Chemical Society, 2016-08-01) [Resenha]
Psychotria genus (Rubiaceae) is featured into the angiosperm, being the most speciose genus comprising approximately 1600 species. The available references demonstrate that Psychotria has several uses on traditional medicine ...