Determination of ambroxol in syrups using diffuse reflectance spectroscopy
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Data
2009-01-01
Autores
Rufino, José L. [UNESP]
Santos, Joel M. [UNESP]
Rodrigues, Mayra A. [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
This paper reports an analytical method for the determination of ambroxol in micellar medium by spot test-diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (λ= 520 nm) produced from the reaction between ambroxol and p-dimethylaminocinnamaldehyde on the surface filter paper. The linear range was from 1.21 × 103 to 9.65 × 103 mol L-1 (500 - 4000 μg mL-1). The limit of detection and quantification were 3.50 x 10-4 mol L-1 (145 μg mL-1) and 1.16 x 10-3 mol L-1 (481 μg mL-1), respectively. Five commercial samples were analysed and the results obtained by the proposed method were in good agreement with those obtained by the literature method at 95% confidence level.
Descrição
Palavras-chave
ambroxol, diffuse reflectance spectroscopy, p-dimethylaminocinnamaldehyde
Como citar
Química Nova. Sociedade Brasileira de Química, v. 32, n. 6, p. 1513-1516, 2009.