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dc.contributor.authorDumont, Frederic S.
dc.contributor.authorBiancardi, Vivian [UNESP]
dc.contributor.authorKinkead, Richard
dc.date.accessioned2014-05-20T13:15:41Z
dc.date.available2014-05-20T13:15:41Z
dc.date.issued2011-02-15
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2010.12.004
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 175, n. 2, p. 288-295, 2011.
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11449/2758
dc.description.abstractNeonatal maternal separation (NMS) is a form of stress that interferes with the regulation of the stress response, an effect that predisposes to the emergence of panic and anxiety related disorders. We previously showed that at adulthood, awake female (but not male) rats subjected to NMS show a hypercapnic ventilatory response (HCVR; 5% CO(2)) that is 63% greater than controls (Genest et al., 2007). To understand the mechanisms underlying the sex-specific effects of NMS on the ventilatory response to CO(2), we used two different anesthetized female rat preparations to assess central CO(2) chemosensitivity and contribution of sensory afferents (stretch receptors and peripheral chemoreceptors) that influence the HCVR. Data show that anesthesia eliminated the respiratory phenotype observed previously in awake females and CO(2) chemosensitivity did not differ between groups. Finally, the assessment of the ovarian hormone levels across the oestrus cycle failed to reveal significant differences between groups. Since anesthesia did not affect the manifestation of NMS-related respiratory dysfunction in males (including the hypercapnic ventilatory response) (Kinkead et al., 2005; Dumont and Kinkead, 2010), we propose that the panic or anxiety induced by CO(2) during wakefulness is responsible for enhancement of the HCVR in NMS females. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipCanada Research Chair in Respiratory Neurobiology
dc.description.sponsorshipla Fondation des Etoiles for children's health research
dc.format.extent288-295
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.sourceWeb of Science
dc.subjectControl of breathingen
dc.subjectStressen
dc.subjectSexual dimorphismen
dc.titleHypercapnic ventilatory response of anesthetized female rats subjected to neonatal maternal separation: Insight into the origins of panic attacks?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniv Laval
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Laval, Univ Quebec, Ctr Hosp, Ctr Rech,Dept Pediat, Quebec City, PQ, Canada
dc.description.affiliationSão Paulo State Univ, UNESP, FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, FCAV, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.identifier.doi10.1016/j.resp.2010.12.004
dc.identifier.wosWOS:000287546200014
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
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