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dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorGonçalves, Marcos Moisés
dc.contributor.authorMoraes, Carolina Morales
dc.contributor.authorAraújo, Daniele Ribeiro de
dc.contributor.authorZanella, Luciana
dc.contributor.authorPaula, Eneida de
dc.contributor.authorPertinhez, Thelma de Aguiar
dc.date.accessioned2014-05-20T15:10:23Z
dc.date.available2014-05-20T15:10:23Z
dc.date.issued2007-10-01
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422007000500028
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1203-1207, 2007.
dc.identifier.issn0100-4042
dc.identifier.urihttp://hdl.handle.net/11449/27605
dc.description.abstractCharacteriza of the inclusion complex ropivacaine: β-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1203-1207
dc.language.isopor
dc.publisherSociedade Brasileira de Química
dc.relation.ispartofQuímica Nova
dc.sourceSciELO
dc.subjectropivacaineen
dc.subjectcyclodextrinen
dc.subjectNMRen
dc.titleCaracterização do complexo de inclusão ropivacaína: β-ciclodextrinapt
dc.title.alternativeCharacterization of the inclusion complex ropivacaine: β-cyclodextrinen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de Sorocaba (UNISO)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de Parma
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental
dc.description.affiliationUniversidade de Sorocaba
dc.description.affiliationUniversidade Estadual de Campinas Instituto de Biologia Departamento de Bioquímica
dc.description.affiliationUniversidade de Parma Departamento de Medicina Experimental
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental
dc.identifier.doi10.1590/S0100-40422007000500028
dc.identifier.scieloS0100-40422007000500028
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-36148936330
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, Sorocabapt
dc.identifier.fileS0100-40422007000500028.pdf
dc.relation.ispartofjcr0.646
dc.relation.ispartofsjr0,255
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