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dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.authorHartzler, Lynn K.
dc.contributor.authorPutnam, Robert W.
dc.date.accessioned2014-05-20T13:15:42Z
dc.date.available2014-05-20T13:15:42Z
dc.date.issued2010-10-31
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2010.04.024
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 173, n. 3, p. 264-273, 2010.
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11449/2771
dc.description.abstractThe locus coeruleus (LC) lies in the dorsal pons and supplies noradrenergic (NA) input to many regions of the brain, including respiratory control areas. The LC may provide tonic input for basal respiratory drive and is involved in central chemosensitivity since focal acidosis of the region stimulates ventilation and ablation reduces CO(2)-induced increased ventilation. The output of LC is modulated by both serotonergic and glutamatergic inputs. A large percentage of LC neurons are intrinsically activated by hypercapnia. This percentage and the magnitude of their response are highest in young neonates and decrease dramatically after postnatal day P10. The cellular bases for intrinsic chemosensitivity of LC neurons are comprised of multiple factors, primary among them being reduced extracellular and intracellular pH, which inhibit inwardly rectifying and voltage-gated K(+) channels, and activate L-type Ca(2+) channels. Activation of K(Ca) channels in LC neurons may limit their ultimate response to hypercapnia. Finally, the LC mediates central chemosensitivity and contains pH-sensitive neurons in amphibians, suggesting that the LC has a long-standing phylogenetic role in respiratory control. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipNational Heart Lung and Blood Institute
dc.description.sponsorshipWSU
dc.description.sponsorshipRuth L. Kirschstein National Research Service Award
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia em Fisiologia Comparada (INCT-Fisiologia Comparada)
dc.format.extent264-273
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.sourceWeb of Science
dc.subjectRodenten
dc.subjectAmphibianen
dc.subjectrespirationen
dc.subjectChemosensitive signalingen
dc.subjectSerotoninen
dc.subjectGlutamateen
dc.subjectK channelen
dc.subjectHypercapniaen
dc.subjectDevelopmenten
dc.titleThe locus coeruleus and central chemosensitivityen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionWright State Univ
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationWright State Univ, Boonshoft Sch Med, Dept Neurosci Cell Biol & Physiol, Dayton, OH 45435 USA
dc.description.affiliationSão Paulo State Univ, FCAVJ UNESP, Dept Anim Morphol & Physiol, Jaboticabal, Brazil
dc.description.affiliationWright State Univ, Dept Biol Sci, Dayton, OH 45435 USA
dc.description.affiliationUnespSão Paulo State Univ, FCAVJ UNESP, Dept Anim Morphol & Physiol, Jaboticabal, Brazil
dc.identifier.doi10.1016/j.resp.2010.04.024
dc.identifier.wosWOS:000283567900009
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdNational Heart Lung and Blood Institute: R01 HL56683
dc.description.sponsorshipIdRuth L. Kirschstein National Research Service Award: F32 HL080877
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
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