The contribution of genes required for anaerobic respiration to the virulence of Salmonella enterica serovar Gallinarum for chickens
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Data
2009-12-01
Autores
Paiva, J.B. [UNESP]
Penha Filho, R.A.C. [UNESP]
Pereira, E.A. [UNESP]
Lemos, M.V.F. [UNESP]
Barrow, P.A.
Lovell, M.A.
Berchieri Jr, A. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Microbiologia
Resumo
Salmonella enterica serovar Gallinarum (SG) is an intracellular pathogen of chickens. To survive, to invade and to multiply in the intestinal tract and intracellularly it depends on its ability to produce energy in anaerobic conditions. The fumarate reductase (frdABCD), dimethyl sulfoxide (DMSO)-trimethylamine N-oxide (TMAO) reductase (dmsABC), and nitrate reductase (narGHIJ) operons in Salmonella Typhimurium (STM) encode enzymes involved in anaerobic respiration to the electron acceptors fumarate, DMSO, TMAO, and nitrate, respectively. They are regulated in response to nitrate and oxygen availability and changes in cell growth rate. In this study mortality rates of chickens challenged with mutants of Salmonella Gallinarum, which were defective in utilising anaerobic electron acceptors, were assessed in comparison to group of bird challenged with wild strain. The greatest degree of attenuation was observed with mutations affecting nitrate reductase (napA, narG) with additional attenuations induced by a mutation affecting fumarate reductase (frdA) and a double mutant (dmsA torC) affecting DMSO and TMAO reductase.
Descrição
Palavras-chave
Salmonella Gallinarum, anaerobic genes, poultry, mutations
Como citar
Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 40, n. 4, p. 994-1001, 2009.