Preparation and antimicrobial activity of gelatin microparticles containing propolis against oral pathogens
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Data
2006-01-01
Autores
Bruschi, M. L.
Lara, EHG
Martins, CHG
Vinholis, AHC
Casemiro, L. A.
Panzeri, H.
Gremiao, MPD
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Editor
Taylor & Francis Inc
Resumo
Gelatin microparticles containing propolis ethanolic extractive solution were prepared by spray-drying technique. Particle,, with regular morphology, mean diameter ranging of 2.27 mu m to 2.48 mu m, and good entrapment efficiency for propolis were obtained. The in vitro antimicrobial activity of microparticles was evaluated against microorganisms of oral importance (Enterococcus faecalis, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus mitis, Streptococcus mutans, Streptococcus sobrinus, Candida albicans, and Lactobacillus casei). The utilized techniques were diffusion in agar and determination of minimum inhibitory concentration. The choice of the method to evaluate the antimicrobial activity of microparticles showed be very important. The microparticles displayed activity against all tested strains of similar way to the propolis, showing greater activity against the strains of E. salivarius, S. sanguinis, S. mitis, and C albicans.
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Palavras-chave
propolis, gelatin microparticles containing propolis, antimicrobial activity, oral pathogens
Como citar
Drug Development and Industrial Pharmacy. Philadelphia: Taylor & Francis Inc., v. 32, n. 2, p. 229-238, 2006.