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dc.contributor.authorNeto, J. B.
dc.contributor.authorVieira, JGH
dc.contributor.authorShuhama, T.
dc.contributor.authorRusso, EMK
dc.contributor.authorPiesco, R. V.
dc.contributor.authorCuri, P. R.
dc.date.accessioned2014-05-20T15:22:29Z
dc.date.available2014-05-20T15:22:29Z
dc.date.issued1991-02-01
dc.identifierhttp://dx.doi.org/10.1007/BF02863078
dc.identifier.citationBiological Trace Element Research. Totowa: Humana Press Inc., v. 28, n. 2, p. 123-133, 1991.
dc.identifier.issn0163-4984
dc.identifier.urihttp://hdl.handle.net/11449/33448
dc.description.abstractReports in the literature have shown that acute or chronic zinc administration may cause hyperglycemia, with a fall in serum or insular insulin occurring in experimental animals. on the other hand, under conditions of both acute and chronic hyperglycemia, an increase, a decrease, or a normal level of blood zinc has been observed in studies conducted on humans. Thus, the objective of the investigation described here was to determine the relationship existing among zinc, glucose, and insulin under acute conditions. Thirty-six subjects of both sexes (mean age, 23 yr) were tested at 7:00 A.M. after a 12-h fast. Two antecubital veins of both forearms were punctured and maintained with physiological saline. Three experiments were performed in which zinc was administered orally, and hypertonic glucose and tolbutamid were administered intravenously. Blood samples were then collected over a period ranging from 93 to 240 min after the basal times of - 30 and 0 min. Hyperzincemia did not cause changes in plasma glucose or insulin either in the absence of or during perfusion of glucose. Hyperglycemia, hypoglycemia, and hyperinsulinemia did not modify serum zinc levels. These results demonstrate that acute zinc administration did not change carbohydrate metabolism and that sudden variations in glucose and insulin levels did not modify the serum profile of zinc.en
dc.format.extent123-133
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.sourceWeb of Science
dc.titleINTERACTION AMONG ZINC, GLUCOSE, AND INSULIN IN NORMAL INDIVIDUALS DURING GLUCOSE AND TOLBUTAMIDE PERFUSIONen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dcterms.rightsHolderHumana Press Inc
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUNIV SAO PAULO,FAC CIENCIAS FARMACEUT RIBEIRAO PRETO,BR-14049 RIBEIRAO PRETO,SP,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED SCH,BR-04023 SAO PAULO,BRAZIL
dc.identifier.doi10.1007/BF02863078
dc.identifier.wosWOS:A1991FA53000005
dc.rights.accessRightsAcesso restrito
dc.relation.ispartofjcr2.361
dc.relation.ispartofsjr0,719
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