Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids
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2003-07-01
Autores
Cardoso, C. L.
Silva, DHS
Tomazela, D. M.
Verli, H.
Young, MCM
Furlan, Maysa [UNESP]
Eberlin, M. N.
Bolzani, Vanderlan da Silva [UNESP]
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Amer Chemical Soc
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Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data. An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 66, n. 7, p. 1017-1021, 2003.