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dc.contributor.authorCora, L. A.
dc.contributor.authorRomeiro, Fernando Gomes [UNESP]
dc.contributor.authorStelzer, M.
dc.contributor.authorAmerico, M. F.
dc.contributor.authorOliveira, R. B.
dc.contributor.authorBaffa, O.
dc.contributor.authorMiranda, JRA
dc.date.accessioned2014-05-20T15:22:50Z
dc.date.available2014-05-20T15:22:50Z
dc.date.issued2005-06-15
dc.identifierhttp://dx.doi.org/10.1016/j.addr.2005.01.026
dc.identifier.citationAdvanced Drug Delivery Reviews. Amsterdam: Elsevier B.V., v. 57, n. 8, p. 1223-1241, 2005.
dc.identifier.issn0169-409X
dc.identifier.urihttp://hdl.handle.net/11449/33750
dc.description.abstractConventionally, pharmaceutical substances are administered orally because the gastrointestinal tract possesses the appropriate features for drug absorption. Nevertheless, the gastrointestinal tract physiology is complex and influenced by many factors. These factors must be completely understood for the optimization of oral drug delivery systems. Although in vitro tests provide information about release and drug absorption profiles, in vivo studies are essential, due to the biological variability. Several techniques have been employed in an attempt to conveniently characterize the behavior of solid dosage forms in vivo. The noninvasive biomagnetic technique of alternate current biosusceptometry (ACB) has been used in studies focusing on gastrointestinal motility and, more recently, to evaluate the performance of magnetic dosage forms. This article will discuss the main characteristics of AC biosusceptometry and its applicability for determination of the relationship between the human gastrointestinal tract and orally administered pharmaceutical dosage forms. (c) 2005 Elsevier B.V. All rights reserved.en
dc.format.extent1223-1241
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAdvanced Drug Delivery Reviews
dc.sourceWeb of Science
dc.subjectAC susceptometerpt
dc.subjectgastrointestinal motilitypt
dc.subjectsolid dosage formspt
dc.subjectbiomagnetic measurementpt
dc.subjectmagnetic markerpt
dc.subjectmagnetic tracerpt
dc.titleAC biosusceptometry in the study of drug deliveryen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationInst Biociencias, Dept Fis & Biofis, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Lab Biomagnetismo, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Filosofia Ciências & Letras Ribeirao Pret, Dept Fis & Matemat, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Lab Biomagnetismo, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.addr.2005.01.026
dc.identifier.wosWOS:000230043800009
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.author.orcid0000-0002-0622-2814[6]
unesp.author.orcid0000-0001-8242-3653[1]
unesp.author.orcid0000-0002-8306-8056[7]
dc.relation.ispartofjcr13.660
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