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dc.contributor.authorClaudino, M. A.
dc.contributor.authorPriviero, F. B. M.
dc.contributor.authorCamargo, E. A.
dc.contributor.authorTeixeira, C. E.
dc.contributor.authorDe Nucci, G.
dc.contributor.authorAntunes, E.
dc.contributor.authorZanesco, A.
dc.date.accessioned2014-05-20T15:22:52Z
dc.date.available2014-05-20T15:22:52Z
dc.date.issued2007-03-01
dc.identifierhttp://dx.doi.org/10.1038/sj.ijir.3901511
dc.identifier.citationInternational Journal of Impotence Research. London: Nature Publishing Group, v. 19, n. 2, p. 189-195, 2007.
dc.identifier.issn0955-9930
dc.identifier.urihttp://hdl.handle.net/11449/33782
dc.description.abstractThe aim of this work was to evaluate the influence of run training on the responsiveness of corpus cavernosum (CC) from rats made hypertensive by treatment with nitric oxide (NO) synthesis inhibitor. Wistar rats were divided into sedentary control (C-SD), exercise training (C-TR), N(omega)-nitro-L-arginine methyl ester (L-NAME) sedentary (LN-SD) and L-NAME trained (LN-TR) groups. The run training program consisted in 8 weeks in a treadmill, 5 days/week, each session lasted 60 min. L-NAME treatment (2 and 10mg/rat/day) started after 4 weeks of prior physical conditioning and lasted 4 weeks. Concentration-response curves were obtained for acetylcholine (ACh), sodium nitroprusside (SNP), sildenafil and BAY 41-2272. The effect of electrical field stimulation (EFS) on the relaxations responses of CC was evaluated. Run training prevented the arterial hypertension induced by L-NAME treatment (LN-SD: 135+/-2 and 141+/-2 mm Hg for both doses of L-NAME) compared to LN-SD groups (154+/-1 and 175+/-2 mm Hg, for 2 and 10 mg of L-NAME, respectively). Run training produced an increase in the maximal responses (E(max)) of CC for ACh (C-SD: 47+/-3; C-TR: 5271; and LN-TR: 53+/-3%) and SNP (C-SD: 8971; C-TR: 9871; and LN-TR: 95+/-1%). Both potency and E(max) for ACh were reduced in a dose of 10 mg of L-NAME, and run training restored the reduction of E(max) for ACh. No changes were found for BAY 41-2271 and sildenafil. Relaxing responses to EFS was reduced by L-NAME treatment that was restored by prior physical conditioning. In conclusion, our study shows a beneficial effect of prior physical conditioning on the impaired CC relaxing responses in rats made hypertensive by chronic NO blockade.en
dc.format.extent189-195
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofInternational Journal of Impotence Research
dc.sourceWeb of Science
dc.subjectcorpus cavernosumpt
dc.subjectnitric oxidept
dc.subjectarterial hypertensionpt
dc.subjectrelaxing responsept
dc.subjectphysical exercisept
dc.titleProtective effect of prior physical conditioning on relaxing response of corpus cavernosum from rats made hypertensive by nitric oxide inhibitionen
dc.typeArtigo
dcterms.licensehttp://www.nature.com/authors/policies/confidentiality.html
dcterms.rightsHolderNature Publishing Group
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Educ Phys, BR-13506900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Educ Phys, BR-13506900 São Paulo, Brazil
dc.identifier.doi10.1038/sj.ijir.3901511
dc.identifier.wosWOS:000244956100012
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
dc.identifier.lattes4472007237545596
unesp.author.lattes4472007237545596
unesp.author.orcid0000-0002-4346-7941[5]
unesp.author.orcid0000-0003-2201-8247[6]
unesp.author.orcid0000-0002-3590-9607[1]
unesp.author.orcid0000-0002-6022-2081[2]
dc.relation.ispartofjcr1.517
dc.relation.ispartofsjr0,575
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