Genetic analysis of phosphoprotein and matrix protein of rabies viruses isolated in Brazil

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Data

2007-11-01

Autores

Kobayashi, Yuki
Okuda, Hiromi
Nakamura, Kana
Sato, Go
Itou, Takuya
Carvalho, Adolorata A. B. [UNESP]
Silva, Marlon V.
Mota, Carla S.
Ito, Fumio H.
Sakai, Takeo

Título da Revista

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Editor

Japan Soc Vet Sci

Resumo

To investigate the genetic characteristics of phosphoprotein (P) and matrix protein (M) genes of variable rabies virus (RV) prevalent in Brazil, the authors genetically characterized the P and M genes from 30 Brazilian RV field isolates. Phylogenetic analysis based on the P and M genes revealed the presence of six RV variants that consisted primarily of three insectivorous bats, the vampire bat, dog and fox in Brazil. Specific amino acid substitutions corresponding to these phylogenetic lineages were observed, with ASP(42) and GlU(62) in the P protein found to be characteristic of Brazilian chiroptera- and carnivora-related RVs, respectively. Amino acid sequence motifs predicted to associate with a viral function in the P and M proteins were conserved among Brazilian RV variants.

Descrição

Palavras-chave

Brazil, genetic analysis, matrix protein, phosphoprotein, rabies virus

Como citar

Journal of Veterinary Medical Science. Tokyo: Japan Soc Vet Sci, v. 69, n. 11, p. 1145-1154, 2007.