Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
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Data
1999-08-01
Autores
Cruz, AJG
Silva, A. S.
Araujo, MLGC
Giordano, R. C.
Hokka, C. O.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Cephalosporin C production process optimization was studied based on four experiments carried out in an agitated and aerated tank fermenter operated as a fed-batch reactor. The microorganism Cephalosporium acremonium ATCC 48272 (C-10) was cultivated in a synthetic medium containing glucose as major carbon and energy source. The additional medium contained a hydrolyzed sucrose solution as the main carbon and energy source and it was added after the glucose depletion. By manipulating the supplementary feed rate, it was possible to increase antibiotic production. A mathematical model to represent the fed-batch production process was developed. It was observed that the model was applicable under different operation conditions, showing that optimization studies can be made based on this model. (C) 1999 Elsevier B.V. Ltd. All rights reserved.
Descrição
Palavras-chave
cephalosporin C, beta-lactam, Cephalosporium acremonium, invert sugar, fed-batch, bioprocess optimization
Como citar
Chemical Engineering Science. Oxford: Pergamon-Elsevier B.V., v. 54, n. 15-16, p. 3137-3142, 1999.