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dc.contributor.authorDasilva, RKP
dc.contributor.authorSaad, W. A.
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorCamargo, LAD
dc.date.accessioned2014-05-20T15:23:50Z
dc.date.available2014-05-20T15:23:50Z
dc.date.issued1995-06-25
dc.identifierhttp://dx.doi.org/10.1016/0165-1838(94)00176-K
dc.identifier.citationJournal of the Autonomic Nervous System. Amsterdam: Elsevier B.V., v. 53, n. 2-3, p. 195-204, 1995.
dc.identifier.issn0165-1838
dc.identifier.urihttp://hdl.handle.net/11449/34537
dc.description.abstractIn this-study we investigated the influence of electrolytic lesion of the lateral hypothalamus (LH) on the water and salt appetite, and the natriuretic, diuretic and cardiovascular effects induced by angiotensinergic, cholinergic and noradrenergic stimulation of the median preoptic nucleus (MnPO) in rats. Male Holtzman rats were implanted with a cannula into the MnPO. Other groups of sham- and LH-lesioned rats received a stainless steel cannula implanted into the MnPO. ANGII injection into the MnPO induced water and sodium intake, and natriuretic, diuretic, presser and tachycardic responses. Carbachol induced water intake, and natriuretic, presser and bradycardic responses, whereas noradrenaline increased urine, sodium excretion and blood pressure, and induced bradycardia. In rats submitted to LH-lesion only, water and sodium intake was reduced compared with sham rats. LH lesion also reduced the sodium ingestion induced by ANGII (12 ng) into the MnPO. In LH-lesioned rats, the dipsogenic, diuretic and presser responses induced by ANGII (12 ng), carbachol (2 nmol) and noradrenaline (20 nmol) injection into the MnPO were reduced. The same occurred with sodium excretion when carbachol (2 nmol) and noradrenaline (20 nmol) were injected into the MnPO of LH-lesioned rats, whereas ANGII(12 ng) induced an increase in sodium excretion. These data show that electrolytic lesion of the LH reduces fluid and sodium intake, and presser responses to angiotensinergic, cholinergic and noradrenergic activation of the MnPO. LH involvement with MnPO excitatory and inhibitory mechanisms related to water and sodium intake, sodium excretion and cardiovascular control is suggested.en
dc.format.extent195-204
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the Autonomic Nervous System
dc.sourceWeb of Science
dc.subjectINGESTIONpt
dc.subjectEXCRETIONpt
dc.subjectANGIOTENSIN IIpt
dc.subjectCARBACHOLpt
dc.subjectNORADRENALINEpt
dc.titleEFFECT OF LATERAL HYPOTHALAMUS LESIONS ON THE WATER AND SALT INTAKE, AND SODIUM AND URINE EXCRETION INDUCED BY ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN CONSCIOUS RATSen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationPAULISTA STATE UNIV,SCH DENT,DEPT PATHOL,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV,SCH DENT,DEPT PATHOL,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.identifier.doi10.1016/0165-1838(94)00176-K
dc.identifier.wosWOS:A1995RG02000013
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[4]
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