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dc.contributor.authorPinheiro Junqueira, Marcos Emerson
dc.contributor.authorGrund, Lidiane Zito
dc.contributor.authorOrii, Noemia M.
dc.contributor.authorSaraiva, Tania Cristina
dc.contributor.authorde Magalhaes Lopes, Carlos Alberto
dc.contributor.authorLima, Carla
dc.contributor.authorLopes-Ferreira, Moica
dc.date.accessioned2014-05-20T15:24:45Z
dc.date.available2014-05-20T15:24:45Z
dc.date.issued2007-06-01
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2007.01.004
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 49, n. 7, p. 909-919, 2007.
dc.identifier.issn0041-0101
dc.identifier.urihttp://hdl.handle.net/11449/35306
dc.description.abstractCathorops spixii is one of the most abundant venomous fish of the southeastern coast of the State of São Paulo, and consequently causes a great part of the accidents seen there. The accidents affect mainly fishermen, swimmers and tourists and are characterized by punctiform or wide wounds, erythema, edema, pain, sudoresis, indisposition, fever, nausea, vomiting and secondary infection. The objective of this work was to characterize the inflammatory response induced in mice by both venoms (mucus and sting) of the catfish C spixii. Our results demonstrated that both venoms induced a great number of rolling and adherent leukocytes in the post-capillary venules of cremaster muscle of mice, and an increase in the vascular permeability in peritoneal cavity. Mucus induced the recruitment of neutrophils immediately after injection followed later by macrophage infiltration. In contrast, the cellular infiltration elicited by sting venom was rapidly resolved. The peritonitis reaction provoked by venoms was characterized by cytokine (IL-6), chemokines (MCP-1 and KC) or lipid mediator (LTB4) production in the peritoneal cavity. The macrophages from 7-day mucus venom-induced exudates upon in vitro mucus venom stimulation, expressed CD1 Ic x MHC class II and release bioactive IL-12p70. on the other hand, sting venom-elicited peritoneal macrophages lost the ability to differentiate into dendritic cells, following re-stimulation in vitro with sting venom, they do not express CD11c, nor do they exhibit sufficient levels of MHC class II. In conclusion, both types of venoms (mucus or sting) promote inflammatory reaction with different profiles, and the inflammatory reaction induced by the first was characterized by antigen persistence in peritoneal cavity that allowed the activation of phagocytic cells with capacity of antigenic presentation. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.format.extent909-919
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicon
dc.sourceWeb of Science
dc.subjectcatfish venomspt
dc.subjectCathorops spixiipt
dc.subjectinnate immunitypt
dc.subjectmacrophage activationpt
dc.subjectantigen presentationpt
dc.titleAnalysis of the inflammatory reaction induced by the catfish (Cathorops spixii) venomsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationInstituto Butantan, Special Lab Appl Toxinol & Immunopathol, São Paulo, Brazil
dc.description.affiliationUNESP, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo, Trop Med Lab, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Sch Med, Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.toxicon.2007.01.004
dc.identifier.wosWOS:000246943700003
dc.rights.accessRightsAcesso restrito
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
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