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dc.contributor.authorCalegari, Leonardo
dc.contributor.authorGorenstein, Clarice
dc.contributor.authorGentil, Valentim
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorNunes-De-Souza, Ricardo Lutz
dc.date.accessioned2014-05-20T15:26:09Z
dc.date.available2014-05-20T15:26:09Z
dc.date.issued2007-08-01
dc.identifierhttp://dx.doi.org/10.1248/bpb.30.1541
dc.identifier.citationBiological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 30, n. 8, p. 1541-1546, 2007.
dc.identifier.issn0918-6158
dc.identifier.urihttp://hdl.handle.net/11449/36364
dc.description.abstractLong-term treatment with clomipramine (CMI), a tricyclic antidepressant, induces food craving and body weight gain in patients. The present study investigated the effects of chronic treatment with CMI on total food intake, macronutrient selection, and body weight gain in rats. Male Wistar rats were maintained on a dietary self-selection regime with separate sources of protein, fat and carbohydrate. Animals received i.p. injections of CMI (0, 3, 10, 30 mg/kg) during 27 consecutive days. Food consumption and body weight were recorded daily and results were calculated as average of three consecutive days, namely during pre-treatment (3 d before pharmacological treatment), treatment (7th-9th; l6th-l8th and 25th-27th days), and post-treatment (28th-33rd days). Results showed that CMI (30 mg/kg) significantly decreased energy intake during all treatment period, an effect that was related to a decrease in both carbohydrate-rich diet intake and body weight gain. At dose of 3 mg/kg CMI increased the total energy intake in the 16th-18th days, suggesting an apparent biphasic effect of chronic treatment with CMI on caloric intake. Chronic administration with CMI (27 d) did not alter protein-rich or fat-rich diet consumption. The main result of this study indicated that chronic treatment with CMI decreases rather than increase food consumption and body weight gain in rats exposed to a macronutrient self-selection procedure.en
dc.format.extent1541-1546
dc.language.isoeng
dc.publisherPharmaceutical Soc Japan
dc.relation.ispartofBiological & Pharmaceutical Bulletin
dc.sourceWeb of Science
dc.subjectmacronutrient self-selectionpt
dc.subjectchronic treatmentpt
dc.subjectclomipraminept
dc.subjectcarbohydratept
dc.subjectfatpt
dc.subjectproteinpt
dc.subjectratpt
dc.titleEffect of chronic treatment with Clomipramine on food intake, macronutrient selection and body weight gain in ratsen
dc.typeArtigo
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
dcterms.rightsHolderPharmaceutical Soc Japan
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationSão Paulo State Univ, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Lab Neuropsychopharmacol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Med Ctr, Dept & Inst Psychiat, BR-01060970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UFSCar Convenio, Programa Pos Graduacao Ciências Fisiol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UFSCar Convenio, Programa Pos Graduacao Ciências Fisiol, São Paulo, Brazil
dc.identifier.doi10.1248/bpb.30.1541
dc.identifier.wosWOS:000249363300033
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.fileWOS000249363300033.pdf
dc.identifier.lattes2514762545280942
unesp.author.lattes2514762545280942
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
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