Biological activities of constituents from Psychotria spectabilis
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Data
2004-12-01
Autores
Benevides, PJC
Young, MCM
Bolzani, Vanderlan da Silva [UNESP]
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Editor
Taylor & Francis Inc
Resumo
In a biological and phytochemical study on the leaves of Psychotria spectabilis Steyerm., seven compounds were isolated and identified from the CHCl3/MeOH (2:1, v/v) and MeOH extracts. Among the isolates were two diterpenes, solidagenone and deoxysolidagenone; three coumarins, coumarin, umbelliferone, and psoralene; and two flavonols, quercetin and quercetrin. Biological evaluations showed that diterpenes and coumarins exhibited antifungal activity against the filamentous fungi Cladosporium cladosporioides (Fresen) de Vries and C sphaerospermum Penzig. Solidagenone and psoralene also displayed selective cytotoxic activity against Rad 52Y mutant yeast strain of Saccharomyces cerevisiae. In this paper, the isolation, structure elucidation, and bioactivity results of these compounds are reported.
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antifungal compounds, bioactivity-directed isolation, DNA-damaging activities, Psychotria spectabilis, Rubiaceae
Como citar
Pharmaceutical Biology. Philadelphia: Taylor & Francis Inc., v. 42, n. 8, p. 565-569, 2004.