SUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE
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Data
1995-03-01
Autores
Novelli, ELB
Rodrigues, N. L.
Ribas, B. O.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Stockton Press
Resumo
Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg(-1)). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds.
Descrição
Palavras-chave
NICKEL, SUPEROXIDE RADICAL, TOXICITY, SUPEROXIDE DISMUTASE, RATS
Como citar
Human & Experimental Toxicology. Basingstoke: Stockton Press, v. 14, n. 3, p. 248-251, 1995.