Show simple item record

dc.contributor.authorSant'Ana, M. G.
dc.contributor.authorSpinosa, H. S.
dc.contributor.authorFlorio, J. C.
dc.contributor.authorBernardi, M. M.
dc.contributor.authorOliveira, C. A.
dc.contributor.authorSarkis, JES
dc.contributor.authorKakazu, M. H.
dc.date.accessioned2014-05-20T15:26:49Z
dc.date.available2014-05-20T15:26:49Z
dc.date.issued2001-03-01
dc.identifierhttp://dx.doi.org/10.1016/S0892-0362(01)00118-0
dc.identifier.citationNeurotoxicology and Teratology. Oxford: Pergamon-Elsevier B.V., v. 23, n. 2, p. 203-212, 2001.
dc.identifier.issn0892-0362
dc.identifier.urihttp://hdl.handle.net/11449/36906
dc.description.abstractThe effects of maternal exposure to lead (Pb) during the perinatal ( 1% and 0.1% Pb) periods of sexual brain differentiation were studied in adult male offspring. Maternal Pb levels were measured after treatment. Behavioral (open field and sexual behavior), physical (sexual maturation, body and organ weights), and biochemical (testosterone levels and hypothalamic monoamine and respective metabolite levels) data were assessed in perinatally exposed offspring. The effects of gonadrotopin-releasing hormone (GnRH) administration to pups at birth on puberty and sexual behavior were also investigated in offspring postnatally exposed to the metal. Results showed that perinatal administration of the two Pb concentrations did not modify maternal weight gain; 1% Pb exposure reduced offspring body weight during the 7 days of treatment while no changes were observed after 0.1% Pb exposure; neither ph concentration altered offspring sexual maturation; the higher Pb concentration improved sexual behavior while the 0.1% concentration reduced it; exposure to 0.1% Pb caused decrease in testis weight, an increase in seminal vesicle weight and no changes in plasma testosterone levels; hypothalamic VMA levels were increased compared to the control group; GnRH administration reversed the effects of 0.1% Ph administration on male sexual behavior. These results show that perinatal exposure to ph had a dose-dependent effect on the sexual behavior of rats and that a decrease in GnRH source in the offspring was probably involved in the reduction of their sexual performance. (C) 2001 Elsevier B.V. All rights reserved.en
dc.format.extent203-212
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeurotoxicology and Teratology
dc.sourceWeb of Science
dc.subjectleadpt
dc.subjectsexual behaviorpt
dc.subjectperinatept
dc.subjectGnRHpt
dc.subjectratpt
dc.titleRole of early GnRH administration in sexual behavior disorders of rat pups perinatally exposed to leaden
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecn, Dept Patol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Hlth Sci Inst, BR-01405 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecn, Dept Reprod, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Hlth Sci Inst, BR-01405 São Paulo, Brazil
dc.identifier.doi10.1016/S0892-0362(01)00118-0
dc.identifier.wosWOS:000168684900010
dc.rights.accessRightsAcesso restrito
dc.relation.ispartofjcr2.811
dc.relation.ispartofsjr0,987
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record