BIOACTIVE AND OTHER PIPERIDINE ALKALOIDS FROM CASSIA-LEPTOPHYLLA
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Data
1995-05-22
Autores
Bolzani, Vanderlan da Silva [UNESP]
Gunatilaka, AAL
Kingston, DGI
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Elsevier B.V.
Resumo
Four new piperidine alkaloids, leptophyllin A (4), 3-acetylleptophyllin A (5), leptophyllin B (8), and (-)-spectaline (1), and 3 known piperidine alkaloids, (-)-spectalinine (2), canavaline (3), and iso-6-canavaline (7), were isolated by a bioassay-guided fractionation of a leaf extract of Cassia leptophylla. The alkaloids 1 - 3 were active in a mechanism-based DNA-modifying yeast assay and 2 was moderately active in Vero monkey and Chinese hamster ovary cell cytotoxicity assays.
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Tetrahedron. Oxford: Pergamon-Elsevier B.V., v. 51, n. 21, p. 5929-5934, 1995.